| Autor: |
Sandra Hervas-Stubbs, Cristian Smerdou, Nathalie Thieblemont, Miguel F. Sanmamed, Maria C. Ochoa, Marta Ruiz-Guillen, Jose I. Riezu-Boj, Erkuden Casales, Uxua Mancheño, Juan R. Rodriguez-Madoz, Juan Dubrot, Mercedes Reboredo, Jose I. Quetglas, Ignacio Melero |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22400862 |
| Popis: |
Supplementary Figures S1-S6. The IFN-I response innduced by SSFV-IL-12 is not affeccted by the IL-12 transgene but is impaired in the absence of IFN-I signaling (S1); IFN-I receptor function is critical for the therapeutic effect of SFV-IL-12 (S2); IFN-I receptor function on the hematopoietic cell compartment is critical for the therapeutic effect of SFV-IL-12 (S3); Gating strategy used to identify TAMs and the different MDSC and DC subsets in the tumor microenvironment (S4); The endogenous IFN-I system lies beneath the effects of SFV-IL-12 on the infiltrates of myeloid cells in the tumor microenvironment (S5); The immune gene expression signature in tumors provoked by SFV-IL-12 is largely dependent on the endogenous IFN-I system (S6). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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