In vitro divergence of HSV-1 populations propagated in different cell lines
| Autor: | Yvonne Michal, Monique Lyon, A. L. Epstein, B. Jacquemont |
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| Rok vydání: | 1990 |
| Předmět: |
Cell type
viruses Population medicine.disease_cause Herpesviridae Virus Cell Line Viral Proteins Serial passage Virology Alphaherpesvirinae medicine Animals Humans Simplexvirus Selection Genetic Serial Passage education Glycoproteins Genetics education.field_of_study biology DNA Restriction Enzymes General Medicine biology.organism_classification Phenotype Cell culture DNA Viral |
| Zdroj: | Archives of Virology. 111:133-140 |
| ISSN: | 1432-8798 0304-8608 |
| DOI: | 10.1007/bf01310511 |
| Popis: | To investigate how the structure of a virus population is influenced by the particular cell types in which the virus is propagated, laboratory populations of HSV-1 have been serially passaged onto a number of different cell lines, differing either in species or in tissue specificity. After a limited number of in vitro passages, several of the daughter virus populations have diverged in the expression of at least one phenotype, suggesting that different cell types have selected different variants contained in the parental virus population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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