Clinical significance of serum laminin and type-IV collagen levels in cutaneous melanoma patients
| Autor: | Derya Duranyildiz, Senem Karabulut, Elif Bilgin, Faruk Tas |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Oncogene biology business.industry Melanoma Articles medicine.disease Molecular medicine Extracellular matrix 030207 dermatology & venereal diseases 03 medical and health sciences Type IV collagen 0302 clinical medicine Oncology Laminin 030220 oncology & carcinogenesis Cutaneous melanoma biology.protein medicine Clinical significance business |
| Zdroj: | Molecular and Clinical Oncology. 5:195-200 |
| ISSN: | 2049-9469 2049-9450 |
| DOI: | 10.3892/mco.2016.873 |
| Popis: | Laminin and type-IV collagen constitute a significant portion of the extracellular matrix. The objective of the present study was to evaluate whether the serum concentrations of laminin and type-IV collagen may serve as biomarkers for cutaneous melanoma. Sixty pathologically confirmed melanoma patients were enrolled in the study. Serum laminin and type-IV collagen levels were assessed using an ELISA. Thirty healthy controls were also examined. No significant differences in the baseline serum levels of laminin were identified between melanoma patients and healthy controls (P=0.45). However, the baseline serum levels of type-IV collagen were significantly elevated in melanoma patients compared with those in the control group (P0.05). Furthermore, the serum levels of laminin and type-IV collagen had no prognostic value regarding the outcome for melanoma patients (P=0.36 and P=0.26, respectively). While laminin levels showed no diagnostic value, the serum concentrations of type-IV collagen were indicated to serve as a diagnostic marker in patients with cutaneous melanoma. In conclusion, type-IV collagen levels may be used as a diagnostic marker for cutaneous melanoma, while being void of any prognostic value. |
| Databáze: | OpenAIRE |
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