Targeting KRAS mutated non-small cell lung cancer: A history of failures and a future of hope for a diverse entity
| Autor: | Alexios Matikas, Dimitrios Mistriotis, Vasilios Georgoulias, Athanasios Kotsakis |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Lung Neoplasms Immune checkpoint inhibitors medicine.medical_treatment Bioinformatics medicine.disease_cause Targeted therapy Proto-Oncogene Proteins p21(ras) 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung medicine Animals Humans Lung cancer business.industry Hematology Prognosis medicine.disease Predictive value 030104 developmental biology Oncology 030220 oncology & carcinogenesis Mutation Adenocarcinoma KRAS Non small cell business |
| Zdroj: | Critical Reviews in Oncology/Hematology. 110:1-12 |
| ISSN: | 1040-8428 |
| DOI: | 10.1016/j.critrevonc.2016.12.005 |
| Popis: | Lung cancer remains the leading cause of cancer-related deaths in both men and women. However, the discovery of several oncogenic driver mutations and the development of immune checkpoint inhibitors resulted in improved clinical outcomes for most patients. Although activating KRAS mutations are the most common recurring molecular events in lung adenocarcinoma, little progress has been made during the past decades with no new agents being approved for this indication. The elucidation of the underlying biology of this diverse patient subgroup offers great potential and renewed hope regarding the rational development, rigorous evaluation and subsequent approval of novel targeted agents and combinations which will effectively suppress compensatory escape routes and the emergence of resistance, issues that have plagued previous attempts. Here, we review in a structured manner all aspects of KRAS positive non-small cell lung cancer, including the molecular biology, clinicopathologic characteristics, the prognostic and predictive value of KRAS mutations, as well as previous and contemporary approaches towards the treatment of this elusive target. |
| Databáze: | OpenAIRE |
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