Luteolin as a modulator of skin aging and inflammation
Autor: | Ute Wölfle, Christoph M. Schempp, Fabian Gendrisch, Philipp R. Esser |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Clinical Biochemistry Anti-Inflammatory Agents Inflammation Pharmacology Biochemistry Skin Aging Proinflammatory cytokine Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Psoriasis medicine Animals Humans Luteolin integumentary system Chemistry General Medicine medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Molecular Medicine medicine.symptom Skin cancer Wound healing |
Zdroj: | BioFactors. 47:170-180 |
ISSN: | 1872-8081 0951-6433 |
Popis: | Luteolin belongs to the group of flavonoids and can be found in flowers, herbs, vegetables and spices. It plays an important role in defending plants, for example against UV radiation by partially absorbing UVA and UVB radiation. Thus, luteolin can also decrease adverse photobiological effects in the skin by acting as a first line of defense. Furthermore, anti-oxidative and anti-inflammatory activities of luteolin were described on keratinocytes and fibroblasts as well as on several immune cells (e.g., macrophages, mast cell, neutrophils, dendritic cells and T cells). Luteolin can suppress proinflammatory mediators (e.g., IL-1β, IL-6, IL-8, IL-17, IL-22, TNF-α and COX-2) and regulate various signaling pathway (e.g., the NF-κB, JAK-STAT as well as TLR signaling pathway). In this way, luteolin modulates many inflammatory processes of the skin. The present review summarizes the recent in vitro and in vivo research on luteolin in the field of skin aging and skin cancer, wound healing as well as inflammatory skin diseases, including psoriasis, contact dermatitis and atopic dermatitis. In conclusion, luteolin might be a promising molecule for the development of topic formulations and systemic agents against inflammatory skin diseases. |
Databáze: | OpenAIRE |
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