Localization of prolactin receptor in the dorsal and ventral skin of the frog (Rana ridibunda)
| Autor: | Serap Sancar, Engin Kaptan, Osman Murathanoglu, Meliha Sengezer Inceli, Songul Suren Castillo |
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| Přispěvatelé: | Istanbul University |
| Rok vydání: | 2010 |
| Předmět: |
Amphibian
endocrine system medicine.medical_specialty Plant Science Biochemistry Frog skin Dermis biology.animal Internal medicine Genetics medicine Receptor Molecular Biology Ecology Evolution Behavior and Systematics Rana ridibunda biology integumentary system Prolactin receptor Myoepithelial cell Cell Biology Immunohistochemistry Prolactin Endocrinology medicine.anatomical_structure Animal Science and Zoology Epidermis Frog Skin hormones hormone substitutes and hormone antagonists |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. The dorsal and ventral skin in amphibians plays an important role in osmoregulation. Prolactin hormone is involved in regulation of amphibian skin functions, such as water and electrolyte balance. Therefore, amphibians may be useful as a model for determining the sites of the prolactin receptor. In this study, prolactin receptor was detected in frog dorsal and ventral skin using immunohistochemical staining method. Prolactin receptor immunoreactivity was localized in all epidermal layers except stratum corneum of dorsal skin epidermis, stratum germinativum layer of ventral skin epidermis, myoepithelial cells, secretory epithelium and secretory channel cells of granular glands in both skin regions. The mucous glands and secretory granules of granular glands did not show immunoreactivity for the prolactin receptor. According to our immunohistochemical results, the more widespread detection of prolactin receptor in dorsal skin epidermis indicates that prolactin is more effective in dorsal skin. Presence of prolactin receptors in epidermis points out its possible osmoregulatory effect. Moreover, detection of receptor immunoreactivity in various elements of poison glands in the dermis of both dorsal and ventral skin regions suggests that prolactin has a regulatory effect in gland functions. © 2009 Institute of Zoology, Slovak Academy of Sciences. This work was supported by the Research Fund of Istanbul University, Project Number: 163/15012004. |
| Databáze: | OpenAIRE |
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