Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study

Autor: Ank de Jonge, Alexandra Zhernakova, Henkjan J. Verkade, Gerard H. Koppelman, Ettje F. Tigchelaar, Jan Sikkema, Jackie A M Dekens, Willemijn D B Warmink-Perdijk, Soesma A Jankipersadsing, Sicco A. Scherjon, Lilian L. Peters, Willem J R Bossers, Cisca Wijmenga, Folkert Kuipers, Sijmen A. Reijneveld
Přispěvatelé: Translational Immunology Groningen (TRIGR), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Public Health Research (PHR), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM), Groningen Research Institute for Asthma and COPD (GRIAC), Department of Health and Life Sciences, Reproductive Origins of Adult Health and Disease (ROAHD), Midwifery Science, APH - Quality of Care, Amsterdam Reproduction & Development (AR&D), APH - Personalized Medicine
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Aging
Epidemiology
Placenta
Cohort Studies
0302 clinical medicine
Surveys and Questionnaires
Prospective Studies
Registries
030212 general & internal medicine
Child
Prospective cohort study
DNA METHYLATION
Biological Specimen Banks
Netherlands
Aged
80 and over
education.field_of_study
Middle Aged
Fetal Blood
Biobank
LUNG-FUNCTION
PREGNANCY
Child
Preschool
Population Surveillance
Cohort
Developmental Origins of Health and Disease (DOHaD)
METABOLIC DISEASE
Female
NUTRITION
Birth cohort
Cohort study
Adult
medicine.medical_specialty
Adolescent
Population
QUESTIONNAIRE
Mothers
CHOLESTASIS
VALIDATION
03 medical and health sciences
Environmental health
THREATENING EXPERIENCES
medicine
Humans
Prospective study
education
Life Style
Aged
Pregnancy
Cohort Profile
Milk
Human
business.industry
Public health
Infant
medicine.disease
LIFE
030104 developmental biology
Transgenerational effects
Microbiome
business
Zdroj: European Journal of Epidemiology, 35(2), 157-168. SPRINGER
European Journal of Epidemiology, 35(2), 157-168. Springer Netherlands
European Journal of Epidemiology
Warmink-Perdijk, W D B, Peters, L L, Tigchelaar, E F, Dekens, J A M, Jankipersadsing, S A, Zhernakova, A, Bossers, W J R, Sikkema, J, de Jonge, A, Reijneveld, S A, Verkade, H J, Koppelman, G H, Wijmenga, C, Kuipers, F & Scherjon, S A 2020, ' Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study ', European Journal of Epidemiology, vol. 35, no. 2, pp. 157-168 . https://doi.org/10.1007/s10654-020-00614-7
ISSN: 0393-2990
Popis: Epidemiological research has shown there to be a strong relationship between preconceptional, prenatal, birth and early-life factors and lifelong health. The Lifelines NEXT is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease in a four-generation design. It is embedded within the Lifelines cohort study, a prospective three-generation population-based cohort study recording the health and health-related aspects of 167,729 individuals living in Northern Netherlands. In Lifelines NEXT we aim to include 1500 pregnant Lifelines participants and intensively follow them, their partners and their children until at least 1 year after birth. Longer-term follow-up of physical and psychological health will then be embedded following Lifelines procedures. During the Lifelines NEXT study period biomaterials—including maternal and neonatal (cord) blood, placental tissue, feces, breast milk, nasal swabs and urine—will be collected from the mother and child at 10 time points. We will also collect data on medical, social, lifestyle and environmental factors via questionnaires at 14 different time points and continuous data via connected devices. The extensive collection of different (bio)materials from mother and child during pregnancy and afterwards will provide the means to relate environmental factors including maternal and neonatal microbiome composition) to (epi)genetics, health and developmental outcomes. The nesting of the study within Lifelines enables us to include preconceptional transgenerational data and can be used to identify other extended families within the cohort.
Databáze: OpenAIRE
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