Effects of tryptophan depletion and tryptophan loading on the affective response to high-dose CO2 challenge in healthy volunteers
| Autor: | Eric Griez, Alessandro Colasanti, Abdul Dandachi, Eva L. van Donkelaar, Jeff L. Oostwegel, Erik den Boer, Annerieke Horlings, Gabriel Esquivel, Koen Schruers |
|---|---|
| Přispěvatelé: | Promovendi MHN, Psychiatrie & Neuropsychologie, RS: MHeNs School for Mental Health and Neuroscience |
| Jazyk: | angličtina |
| Předmět: |
Adult
Male Serotonin medicine.medical_specialty 5-HT Anxiety Stress behavioral disciplines and activities Hypercapnia chemistry.chemical_compound Double-Blind Method Internal medicine mental disorders medicine Humans Amino Acids Psychiatry Neurotransmitter 5-HT receptor Original Investigation Pharmacology Psychological Tests Cross-Over Studies Panic disorder Respiration Tryptophan Panic Fear medicine.disease humanities CO2 challenge Endocrinology chemistry Carbon dioxide Panic Disorder Female medicine.symptom Psychology Anxiety disorder |
| Zdroj: | Psychopharmacology, 215(4), 739-748. Springer Psychopharmacology |
| ISSN: | 0033-3158 |
| DOI: | 10.1007/s00213-011-2177-8 |
| Popis: | Rationale It has been reported that in panic disorder (PD), tryptophan depletion enhances the vulnerability to experimentally induced panic, while the administration of serotonin precursors blunts the response to challenges. Objectives Using a high-dose carbon dioxide (CO2) challenge, we aimed to investigate the effects of acute tryptophan depletion (ATD) and acute tryptophan loading (ATL) on CO2-induced panic response in healthy volunteers. Methods Eighteen healthy volunteers participated in a randomized, double-blind placebo-controlled study. Each subject received ATD, ATL, and a balanced condition (BAL) in separate days, and a double-breath 35% CO2 inhalation 4.5 h after treatment. Tryptophan (Trp) manipulations were obtained adding 0 g (ATD), 1.21 g (BAL), and 5.15 g (ATL) of l-tryptophan to a protein mixture lacking Trp. Assessments consisted of a visual analogue scale for affect (VAAS) and panic symptom list. A separate analysis on a sample of 55 subjects with a separate-group design has also been performed to study the relationship between plasma amino acid levels and subjective response to CO2. Results CO2-induced subjective distress and breathlessness were significantly lower after ATD compared to BAL and ATL (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|