Increased whole body protein breakdown predominates over increased whole body protein synthesis in multiple organ failure
| Autor: | C. M. Scrimgeour, Therese A. Samuels, Kenneth Smith, L. J. Hipkin, J. Arnold, Michael J. Rennie, Ceri J. Green, J. C. Devlin, Ian A. Macdonald, I. T. Campbell |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Resuscitation Hydrocortisone medicine.medical_treatment Multiple Organ Failure Biology Glucagon Leucine Internal medicine medicine Humans Aged Mechanical ventilation Insulin Protein turnover Proteins General Medicine Middle Aged Hormones Protein catabolism Endocrinology Protein Biosynthesis Regression Analysis Female Energy Metabolism Hormone |
| Zdroj: | Clinical science (London, England : 1979). 84(6) |
| ISSN: | 0143-5221 |
| Popis: | 1. Whole body protein turnover was measured using a primed-constant infusion of L-[1−13C]leucine with measurement of breath 13CO2 production and plasma 13C α-ketoisocaproate enrichment. Ten fasting patients, requiring mechanical ventilation and suffering from multiple organ failure, and six healthy control subjects were studied. 2. Protein breakdown and leucine removal from the plasma for protein synthesis were significantly higher in the patients than in the control subjects (P 3. Plasma concentrations of glucose, insulin and growth hormone were not different between the two groups, but those of glucagon (not significant), noradrenaline (P 4. Mean energy expenditure, measured by indirect calorimetry, was 30% higher in the patients than in the healthy control subjects (P 5. Combining the data from both groups of subjects and using multiple regression analysis, cortisol was found to be the most significant predictor of (i) protein breakdown (48% of variance explained), (ii) leucine oxidation (69%) and (iii) hourly energy expenditure (54%). 6. The present investigation using [13C]leucine tracer methods demonstrated, in patients with multiple organ failure, that whole body protein breakdown and synthesis increased concomitantly and were twice as high as rates measured in healthy control subjects. Of the hormones measured in the present study, Cortisol appears to have the most significant effect on whole body protein turnover. |
| Databáze: | OpenAIRE |
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