Parallel changes of blood flow and heterogeneity of capillary plasma perfusion in rat brains during hypocapnia
| Autor: | Helmut Schröck, Karin Zeller, Wolfgang Kuschinsky, Roger Abounader, Roman Duelli, Johannes Vogel |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Physiology Partial Pressure Hemodynamics pCO2 Microcirculation Rats Sprague-Dawley Hypocapnia Capillary Plasma Physiology (medical) Internal medicine medicine Animals Hyperventilation Chemistry Blood flow Carbon Dioxide medicine.disease Capillaries Rats Cerebral blood flow Regional Blood Flow Cerebrovascular Circulation Anesthesia Cardiology Cardiology and Cardiovascular Medicine Perfusion Evans Blue |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 270:H1441-H1445 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.1996.270.4.h1441 |
| Popis: | Plasma perfusion patterns were investigated in brain capillaries during decreased cerebral blood flow induced by hyperventilation. Anesthetized rats were decapitated 3-4 s after being given an intravenous bolus injection of Evans blue dye. the measured steep increase of the arterial dye concentration at this moment ensures that different capillary plasma transit times are reflected in different intracapillary dye concentrations. The observed heterogeneity of capillary plasma transit time was expressed as the coefficient of variation (means +/- SD) of the intracapillary dye concentrations. For comparison, cerebral blood flow was determined at comparable PCO2 values in a second experimental group. At arterial PCO2 values between 40 and 25 mmHg, the cerebral blood flow and the coefficient of variation of the intracapillary dye concentration decreased with decreasing PCO2, whereas at PCO2 values |
| Databáze: | OpenAIRE |
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