Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor–Binding Protein 3 in Relation to the Risk of Type 2 Diabetes Mellitus: Results From the EPIC–Potsdam Study
Autor: | Tobias Pischon, Matthias B. Schulze, Heiner Boeing, Dagmar Drogan |
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Rok vydání: | 2016 |
Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty endocrine system diseases Epidemiology medicine.medical_treatment 030209 endocrinology & metabolism Insulin-like growth factor-binding protein 03 medical and health sciences Insulin-like growth factor 0302 clinical medicine Risk Factors Surveys and Questionnaires Internal medicine medicine Humans Glucose homeostasis Prospective Studies Insulin-Like Growth Factor I Aged biology business.industry Incidence Hazard ratio Case-control study Type 2 Diabetes Mellitus Middle Aged Europe Insulin-Like Growth Factor Binding Protein 3 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Case-Control Studies biology.protein Population study Female business Blood sampling |
Zdroj: | American Journal of Epidemiology. 183:553-560 |
ISSN: | 1476-6256 0002-9262 |
Popis: | Higher levels of insulin-like growth factor-binding protein 3 (IGFBP-3) might raise the risk of type 2 diabetes mellitus (T2DM) via binding of insulin-like growth factor 1 (IGF-1), an insulin-like hormone that is involved in glucose homeostasis. We investigated serum concentrations of IGF-1 and IGFBP-3 and their molar ratio in relation to T2DM incidence in a nested case-cohort study within the European Prospective Investigation Into Cancer and Nutrition-Potsdam Study. We included a randomly selected subcohort of persons without T2DM at the time of blood sampling (n = 2,269) and 776 individuals with incident T2DM identified between 1994 and 2005. For the highest quartile versus lowest, the multivariable-adjusted hazard rate ratios were 0.91 (95% confidence interval (CI): 0.68, 1.23; P for trend = 0.31) for IGF-1, 1.33 (95% CI: 1.00, 1.76; P for trend = 0.04) for IGFBP-3, and 0.77 (95% CI: 0.57, 1.03; P for trend = 0.03) for IGF-1:IGFBP-3 ratio. IGFBP-3 level remained positively associated with T2DM incidence-and the ratio of IGF-1 to IGFBP-3 was inversely related with T2DM incidence--in models that included adjustment for IGF-1 concentrations (P for trend < 0.05). Therefore, our findings do not confirm an association between total IGF-1 concentrations and risk of T2DM in the general study population, although higher IGFBP-3 levels might raise T2DM risk independent of IGF-1 levels. |
Databáze: | OpenAIRE |
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