Does red ginseng ameliorate liver damage caused by obstructive jaundice? : an experimental study
| Autor: | Marlen Süleyman, Ender Ergüder, Koray Koşmaz, Yusuf Murat Bağ, Eylem Pinar Eser, Mevlüt Recep Pekcici, Sema Hücümenoğlu, Mehmet Senes, Abdullah Şenlikci, Mehmet Esat Duymus, Abdullah Durhan, İlknur Alkan Kuşabbi |
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| Rok vydání: | 2021 |
| Předmět: |
Cultural Studies
Linguistics and Language History medicine.medical_specialty business.industry Red ginseng obstructive jaundice anti-inflammatory properties antioxidant properties hepatoprotective effects Gastroenterology Language and Linguistics Ginseng Health Care Sciences and Services Anthropology Internal medicine Medicine Obstructive jaundice Liver damage Sağlık Bilimleri ve Hizmetleri business |
| Zdroj: | Volume: 4, Issue: 2 233-239 Journal of Health Sciences and Medicine |
| ISSN: | 2636-8579 |
| DOI: | 10.32322/jhsm.900023 |
| Popis: | Aim: This experimental study aimed to evaluate the hepatoprotective effect on obstructive jaundice (OJ) of oral red ginseng (RG) extract, which is known to have anti-inflammatory and antioxidant properties. Methods: The rats were randomly separated into 3 groups of 10 rats: the sham group, the control group, and the treatment group. In Group 1 (sham), the common bile duct (CBD) was identified but no ligation or transection was performed. In Group 2 (control), the CBD was identified and ligation and transection were performed, but no treatment was given. In Group 3 (RG group), CBD ligation and transection were performed, then RG extract was administered via an orogastric tube at a dose of 100 mg/ kg/day for 10 days. After 10 days, blood samples were taken for biochemical analysis, and liver tissue samples for biochemical and histopathological analysis. Results: Significantly higher serum albumin levels and lower serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in the RG group than in the control group (p = 0.028, p = 0.001 and p = 0.034, respectively). In the oxidative stress parameters, malondialdehyde (MDA) levels and catalase (CAT) levels were significantly different between the RG group and control group (p = |
| Databáze: | OpenAIRE |
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