Form IV of Carbamazepine
| Autor: | Adam J. Matzger, Jeffrey W. Kampf, Meidong Lang |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Hydrogen
Chemistry Hydrogen bond Stereochemistry Pharmaceutical Science chemistry.chemical_element Hydrogen Bonding Carbamazepine Crystal structure law.invention Crystallography Polymorphism (materials science) law X-ray crystallography medicine Anticonvulsants Crystallization Dimerization Monoclinic crystal system medicine.drug |
| Zdroj: | Journal of Pharmaceutical Sciences. 91:1186-1190 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.10093 |
| Popis: | Carbamazepine has been found to crystallize as a new polymorph that is stable at room temperature. We report the crystal structure of this C-centered monoclinic form (space group C2/c, cell parameters: a = 26.609, b = 6.9269, c = 13.957, beta = 109.702), which consists of hydrogen bonded dimers with an anti-disposition. This represents the third modification of carbamazepine that has been crystallographically characterized, and the fourth for which cell parameters have been determined. Thus, it is designated as form IV of carbamazepine. Differences between the packing of the various polymorphs are discussed. |
| Databáze: | OpenAIRE |
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