Effects of Untreated Drinking Water at Three Indigenous Yaqui Towns in Mexico: Insights from a Murine Model
| Autor: | Osiris Álvarez-Bajo, Mercedes Meza-Montenegro, Guillermo López-Cervantes, Aurora Armienta, Aracely Angulo-Molina, Martín Pedroza-Montero, Alexel Burgara-Estrella, Diego Soto-Puebla, Diana Meza-Figueroa, Sofía Navarro-Espinoza, Erika Silva-Campa |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Veterinary medicine Reactive gliosis Health Toxicology and Mutagenesis chemistry.chemical_element lcsh:Medicine 010501 environmental sciences Biology 01 natural sciences Article murine model 03 medical and health sciences Mice Animals Cities Mexico Arsenic 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences drinking water lcsh:R Public Health Environmental and Occupational Health arsenic Hepatocellular degeneration Disease Models Animal chemistry Murine model manganese indigenous towns Statistical correlation Water Pollutants Chemical Environmental Monitoring |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 18, Iss 805, p 805 (2021) International Journal of Environmental Research and Public Health Volume 18 Issue 2 |
| ISSN: | 1661-7827 1660-4601 |
| Popis: | Background: Reports in a northwestern Mexico state linked arsenic (As) in drinking water to DNA damage in people from indigenous communities. However, this correlation remains under discussion due to unknown variables related to nutrition, customs, and the potential presence of other metal(oid)s. Methods: To determine this association, we sampled water from three Yaqui towns (Có corit, Ví cam, and Pó tam), and analyzed the metals by ICP-OES. We exposed four separate groups, with five male CD-1 mice each, to provide further insight into the potential effects of untreated drinking water. Results: The maximum concentrations of each metal(oid) in µ g· L&minus 1 were Sr(819) > Zn(135) > As(75) > Ba(57) > Mo(56) > Cu(17) > Al(14) > Mn(12) > Se(19). Histological studies revealed brain cells with angulation, satellitosis, and reactive gliosis with significant statistical correlation with Mn and As. Furthermore, the liver cells presented hepatocellular degeneration. Despite the early response, there is no occurrence of both statistical and significative changes in hematological parameters. Conclusions: The obtained results provide experimental insights to understand the potential effects of untreated water with low As and Mn contents in murine models. This fact is noteworthy because of the development of histological changes on both the brain and liver at subchronic exposure. |
| Databáze: | OpenAIRE |
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