How significant is the association between metabolic syndrome and prevalence of colorectal neoplasia?
| Autor: | Miroslav Zavoral, Ondrej Ngo, Nagyija Brogyuk, Ondrej Majek, Stepan Suchanek, Petra Minarikova, Bohumil Seifert, Ladislav Dušek, Bohus Bunganic, Gabriela Vojtechova, Tomáš Grega |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Adenoma medicine.medical_specialty Pathology Colorectal cancer Myocardial Ischemia Review Severity of Illness Index Impaired glucose tolerance 03 medical and health sciences 0302 clinical medicine Diabetes mellitus type 2 Risk Factors Internal medicine Diabetes mellitus medicine Prevalence Secondary Prevention Colorectal neoplasia Humans Mass Screening Neoplasm Invasiveness Obesity Mass screening Czech Republic Metabolic Syndrome business.industry Incidence (epidemiology) Gastroenterology General Medicine Colonoscopy Glucose Tolerance Test medicine.disease digestive system diseases 3. Good health 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Heart ischemic disease Metabolic syndrome business Colorectal Neoplasms Dyslipidemia |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 2219-2840 1007-9327 |
| Popis: | The incidence and prevalence of metabolic syndrome (MS) and colorectal cancer (CRC) has been rising in developed countries. The association between these two diseases has been widely studied and reported. Less evidence is available about the relationship between MS and CRC precancerous lesions (adenomatous polyps, adenomas). The aim of this paper is to present an overview of our scientific understanding of that topic and its implication in clinical practice. One of the principal goals of current CRC secondary prevention efforts is to detect and remove the precancerous lesions in individuals with an average CRC risk to prevent the development of invasive cancer. MS is not currently considered a high-risk CRC factor and is therefore not included in the guidelines of organized screening programs. However, in light of growing scientific evidence, the approach to patients with MS should be changed. Metabolic risk factors for the development of adenomas and cancers are the same - obesity, impaired glucose tolerance, dyslipidemia, hypertension, cardiovascular diseases and diabetes mellitus type 2. Therefore, the key issue in the near future is the development of a simple scoring system, easy to use in clinical practice, which would identify individuals with high metabolic risk of colorectal neoplasia and would be used for individual CRC secondary prevention strategies. Currently, such scoring systems have been published based on Asian (Asia-Pacific Colorectal Screening Score; APCS) and Polish populations. |
| Databáze: | OpenAIRE |
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