Osteocyte-intrinsic mTORC1 signaling restrains trabecular bone accrual in mice
| Autor: | Huilin Yang, Jianquan Chen, Cunchang Liu, Qingbai Liu, Yanjun Yang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Osteoporosis Osteoclasts mTORC1 Mechanistic Target of Rapamycin Complex 1 Biochemistry Osteocytes Bone resorption 03 medical and health sciences Gene Knockout Techniques Mice Bone Density medicine Cortical Bone Animals Bone Resorption Molecular Biology Mechanistic target of rapamycin PI3K/AKT/mTOR pathway Bone Development biology Chemistry Osteoblast Cell Biology Regulatory-Associated Protein of mTOR medicine.disease Cell biology 030104 developmental biology medicine.anatomical_structure Osteocyte Cancellous Bone biology.protein Cortical bone biological phenomena cell phenomena and immunity Signal Transduction |
| Zdroj: | Journal of cellular biochemistry. 119(11) |
| ISSN: | 1097-4644 |
| Popis: | Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) signaling plays important physiological roles in bone homeostasis by regulating multiple steps of osteoblast differentiation as well as its activity. However, its potential role in osteocytes has not been explored. In this study, we deleted Raptor, a specific and essential component of mTORC1, in osteocytes using Dmp1-Cre. Deletion of Raptor in osteocytes did not affect bone development and growth, but caused compartment-specific effects on bone mass. Osteocyte-specific deletion of Raptor had no obvious effect on cortical bone compartments, but led to increased trabecular bone mass. Mechanistically, Raptor deletion resulted in decreased bone resorption without altering bone formation activity. Thus, our study revealed an unexpected role of osteocyte-intrinsic mTORC1 signaling in limiting trabecular bone mass, suggesting that osteocyte-specific inhibition of mTORC1 may be used as a novel approach to treatment of osteoporosis. |
| Databáze: | OpenAIRE |
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