Hypobaric Hypoxia Induces Depression-like Behavior in Female Sprague-Dawley Rats, but not in Males
| Autor: | Perry F. Renshaw, Young Hoon Sung, Shami Kanekar, Kristen E. D'Anci, Paul R. Olson, Olena V. Bogdanova |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Scientific Articles medicine.medical_specialty Physiology Altitude Sickness Motor Activity Salt lake Rats Sprague-Dawley Sex Factors Internal medicine Reaction Time medicine Sprague dawley rats Animals Swimming Depression (differential diagnoses) COPD Behavior Animal Depression business.industry Altitude Public Health Environmental and Occupational Health General Medicine medicine.disease Rat brain Rats Endocrinology Anesthesia Female Hypobaric hypoxia Serotonin business human activities Behavioural despair test |
| Zdroj: | High Altitude Medicine & Biology. 16:52-60 |
| ISSN: | 1557-8682 1527-0297 |
| DOI: | 10.1089/ham.2014.1070 |
| Popis: | Kanekar, Shami, Olena V. Bogdanova, Paul R. Olson, Young-Hoon Sung, Kristen E. D'Anci, and Perry F. Renshaw. Hypobaric hypoxia induces depression-like behavior in female Sprague-Dawley rats, but not males. High Alt Med Biol 16:52–60, 2015—Rates of depression and suicide are higher in people living at altitude, and in those with chronic hypoxic disorders like asthma, chronic obstructive pulmonary disorder (COPD), and smoking. Living at altitude exposes people to hypobaric hypoxia, which can lower rat brain serotonin levels, and impair brain bioenergetics in both humans and rats. We therefore examined the effect of hypobaric hypoxia on depression-like behavior in rats. After a week of housing at simulated altitudes of 20,000 ft, 10,000 ft, or sea level, or at local conditions of 4500 ft (Salt Lake City, UT), Sprague Dawley rats were tested for depression-like behavior in the forced swim test (FST). Time spent swimming, climbing, or immobile, and latency to immobility were measured. Female rats housed at altitude display more depression-like behavior in the FST, with significantly more immobility, less swimming, and lower latency to immobility than those at sea level. In contrast, males in all four altitude groups were similar in their FST behavior. Locomotor behavior in the open field test did not change with altitude, thus validating immobility in the FST as depression-like behavior. Hypobaric hypoxia exposure therefore induces depression-like behavior in female rats, but not in males. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|