The percutaneous absorption of soman in a damaged skin porcine model and the evaluation of WoundStat™ as a topical decontaminant
| Autor: | Charlotte A. Hall, Helen L. Lydon, J. Kevin Chipman, John Jenner, Christopher H. Dalton, John S. Graham, Robert P. Chilcott |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Dorsum medicine.medical_specialty Swine Skin Absorption Soman 0211 other engineering and technologies 02 engineering and technology Pharmacology Toxicology 03 medical and health sciences chemistry.chemical_compound In vivo medicine Distribution (pharmacology) Animals Cholinesterases Tissue Distribution Tissue distribution Chemical Warfare Agents Decontamination Cholinesterase Whole blood Skin 021110 strategic defence & security studies biology Chemistry General Medicine Surgery 030104 developmental biology Percutaneous absorption biology.protein Female Cholinesterase Inhibitors |
| Zdroj: | Cutaneous and ocular toxicology. 37(2) |
| ISSN: | 1556-9535 |
| Popis: | Purpose: The aim of this study was to evaluate a candidate haemostat (WoundStat™), down-selected from previous in vitro studies, for efficacy as a potential skin decontaminant against the chemical warfare agent pinacoyl methylfluorophosphonate (Soman, GD) using an in vivo pig model.Materials and methods: An area of approximately 3 cm2 was dermatomed from the dorsal ear skin to a nominal depth of 100 µm. A discrete droplet of 14C-GD (300 µg kg−1) was applied directly onto the surface of the damaged skin at the centre of the dosing site. Animals assigned to the treatment group were given a 2 g application of WoundStat™ 30 s after GD challenge. The decontamination efficacy of WoundStat™ against GD was measured by the direct quantification of the distribution of 14C-GD, as well as routine determination of whole blood cholinesterase and physiological measurements.Results: WoundStat™ sequestered approximately 70% of the applied 14C-GD. Internal radiolabel recovery from treated animals was approximately ... |
| Databáze: | OpenAIRE |
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