Calcium Phosphate-Based Bioceramics in the Treatment of Osteosarcoma: Drug Delivery Composites and Magnetic Hyperthermia Agents

Autor: Marco Augusto Stimamiglio, Tiê Menezes Oliveira, Sidney Carlos Gasoto, Fernanda Costa Brandão Berti, Lucas Freitas Berti, Bertoldo Schneider
Rok vydání: 2021
Předmět:
Modern medicine
Biocerâmica
chemistry.chemical_element
Biocompatible Materials
Review
02 engineering and technology
Bioceramic
Calcium
010402 general chemistry
01 natural sciences
Durapatita
calcium phosphate
Hidroxiapatita
Materiais Biocompatíveis
Drug Delivery Systems
Osteossarcoma
stomatognathic system
osteosarcoma
Medical technology
medicine
Hyperthermia
magnetic hyperthermia
Hipertermia
R855-855.5
Composite material
Matériaux biocompatibles
Hyperthermie
Systèmes de délivrance de médicaments
Ostéosarcome
Osteosarcoma
Sistemas de Liberação de Medicamentos
bioceramic material
drug-delivery systems
hydroxyapatite
021001 nanoscience & nanotechnology
medicine.disease
Materiales Biocompatibles
Anticancer drug
Combined approach
0104 chemical sciences
Durapatite
Sistemas de Liberación de Medicamentos
Magnetic hyperthermia
chemistry
Drug delivery
0210 nano-technology
Zdroj: Frontiers in Medical Technology, Vol 3 (2021)
Frontiers in Medical Technology
Repositório Institucional da FIOCRUZ (ARCA)
Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
ISSN: 2673-3129
DOI: 10.3389/fmedt.2021.700266
Popis: Universidade Tecnológica Federal do Paraná. Departamento de Engenharia Mecânica. Programa de Pós-Graduação em Engenharia Biomédica. Curitiba, PR, Brasil. Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil. Universidade Tecnológica Federal do Paraná. Departamento de Engenharia Mecânica. Programa de Pós-Graduação em Engenharia Elétrica e Informática Industrial. Curitiba, PR, Brasil. Universidade Tecnológica Federal do Paraná. Departamento de Engenharia Mecânica. Programa de Pós-Graduação em Engenharia Elétrica e Informática Industrial. Curitiba, PR, Brasil. Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil. Universidade Tecnológica Federal do Paraná. Departamento de Engenharia Mecânica. Programa de Pós-Graduação em Engenharia Biomédica. Curitiba, PR, Brasil. The use of biomaterials in medicine is not recent, and in the last few decades, the research and development of biocompatible materials had emerged. Hydroxyapatite (HAp), a calcium phosphate that constitutes a large part of the inorganic composition of human bones and teeth, has been used as an interesting bioceramic material. Among its applications, HAp has been used to carry antitumor drugs, such as doxorubicin, cisplatin, and gemcitabine. Such HAp-based composites have an essential role in anticancer drug delivery systems, including the treatment of osteosarcoma. In addition, the association of this bioceramic with magnetic nanoparticles (MNPs) has also been used as an effective agent of local magnetic hyperthermia. Further, the combined approach of the aforementioned techniques (HAp scaffolds combined with anti-tumor drugs and MNPs) is also an attractive therapeutical alternative. Considering the promising role of the use of bioceramics in modern medicine, we proposed this review, presenting an updated perspective on the use of HAp in the treatment of cancer, especially osteosarcoma. Finally, after giving the current progress in this field, we highlight the urgent need for efforts to provide a better understanding of their potential applications.
Databáze: OpenAIRE
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