Clinical characteristics and prognostic inflection points among long-term survivors of advanced epithelial ovarian cancer
| Autor: | Hee-Sug Ryu, Jiheum Paek, Tae Wook Kong, Kwan-Heup Song, Suk-Joon Chang, Joo-Hyuk Son |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Time Factors Disease Carcinoma Ovarian Epithelial Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Cancer Survivors Internal medicine Republic of Korea medicine Overall survival Retrospective analysis Humans Epithelial ovarian cancer Neoplasms Glandular and Epithelial Stage (cooking) Aged Neoplasm Staging Retrospective Studies Ovarian Neoplasms Advanced ovarian cancer 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Long Term Survivor General Medicine Middle Aged Prognosis Surgery Treatment Outcome Inflection point 030220 oncology & carcinogenesis Female Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | International Journal of Gynecology & Obstetrics. 139:352-357 |
| ISSN: | 0020-7292 |
| DOI: | 10.1002/ijgo.12315 |
| Popis: | Objective To assess clinical characteristics of long-term survivors of advanced epithelial ovarian cancer (EOC) to define a prognostic inflection point for long-term survival. Methods A retrospective analysis was undertaken of patients with FIGO stage III or IV EOC treated at one center in South Korea from 2000 to 2012. Patients who survived 5 years or more were identified, and the periods of disease-free survival and overall survival were evaluated for prognostic inflection points to indicate long-term survival. Clinicopathologic data and treatment-associated factors were assessed. Results In total, 60 patients survived more than 5 years. Thirty-three (55%) patients experienced disease recurrence and 11 (18%) died due to advanced EOC during a median follow-up period of 92 months (range 61–205). Most recurrence events (32/33, 97%) and deaths (10/11, 91%) occurred within 6 years and 8 years, respectively. Although half the long-term (>8 year) survivors with stage IIIC–IV disease experienced disease recurrence, they had a significantly longer platinum-free interval (P=0.007) and tended to have received aggressive surgical treatments after disease recurrence (P=0.054), as compared with survivors for 5–8 years. Conclusion Survival for 8 years might represent a prognostic inflection point for long-term survival in advanced EOC. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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