Synthesis of 1,2-Dihydropyridines Catalyzed by Well-Defined Low-Valent Cobalt Complexes: C-H Activation Made Simple
| Autor: | Marc Petit, Jean-Baptiste Garsi, Etienne Derat, Brendan J. Fallon, Corinne Aubert, Muriel Amatore |
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| Přispěvatelé: | Méthodes et Application en Chimie Organique (MACO), Institut Parisien de Chimie Moléculaire (IPCM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), CNRS, MRES, UPMC, ANR [ANR-12-BS07-0031- 01COCACOLIGHT], Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Activation pathway
well-defined catalyst Stereochemistry Reducing agent mechanistic investigation [CHIM.ORGA]Chemical Sciences/Organic chemistry Regioselectivity chemistry.chemical_element 2-dihydropyridine General Chemistry Combinatorial chemistry cobalt Catalysis chemistry 6 pi-electrocylization Well-defined C-H activation Cobalt |
| Zdroj: | ACS Catalysis ACS Catalysis, 2015, 5 (12), pp.7493-7497. ⟨10.1021/acscatal.5b02138⟩ ACS Catalysis, American Chemical Society, 2015, 5 (12), pp.7493-7497. ⟨10.1021/acscatal.5b02138⟩ |
| ISSN: | 2155-5435 |
| DOI: | 10.1021/acscatal.5b02138⟩ |
| Popis: | International audience; A convenient one-pot system has been developed, allowing the synthesis of highly substituted dihydropyridines via a C-H activation/6 pi-electrocyclization pathway. The reaction proceeds with high regioselectivity, and we disclose the first example of isolated dihydropyridines lacking substitution in the 2 position. Moreover, the use of a simple well-defined low-valent cobalt complex without the need for reducing agents or additives in combination with computational studies provides a clearer insight into the C-H activation pathway than was previously reported. |
| Databáze: | OpenAIRE |
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