EBV-Associated Hodgkin's Disease in an HIV-Infected Child Presenting with a Hemophagocytic Syndrome
| Autor: | Elena De Matteo, Guillermo Drelichman, María Victoria Preciado, Paola Andrea Chabay, Saul Grinstein, Aurelia Fallo |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Epstein-Barr Virus Infections Cancer Research Pathology medicine.medical_specialty Tuberculosis Pediatric AIDS Histiocytosis Non-Langerhans-Cell Lymph node biopsy Hepatosplenomegaly Fatal Outcome Cervical lymphadenopathy Biopsy medicine Humans Fever of unknown origin Child Lymphoma AIDS-Related medicine.diagnostic_test business.industry Hematology medicine.disease Hodgkin Disease Toxoplasmosis Oncology HIV-1 medicine.symptom business |
| Zdroj: | Leukemia & Lymphoma. 42:231-234 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428190109097696 |
| Popis: | An 8-years-old boy was admitted with fever of unknown origin, cervical lymphadenopathy and hepatosplenomegaly and weight loss. His mother's HIV infection was diagnosed two weeks before his hospitalization, so he was diagnosed as perinatally acquired AIDS. Serology and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confirmed on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin's disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry on the lymph node biopsy established the EBV association. On the basis of a sequence of appearance of the clinical, laboratory and histological signs, HIV, EBV or HD may have triggered HS as the last fatal event in this pediatric patient. |
| Databáze: | OpenAIRE |
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