Case Report: Retinitis Pigmentosa Following Cytotoxic Chemotherapy in Usher’s Syndrome
| Autor: | Mark L. Wellemeyer, Paulette Blanchet, Gary V. Burton |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Oncology medicine.medical_specialty Usher syndrome Eye disease medicine.medical_treatment Deafness Internal medicine Antineoplastic Combined Chemotherapy Protocols Retinitis pigmentosa otorhinolaryngologic diseases medicine Humans Cyclophosphamide Chemotherapy business.industry Lymphoma Non-Hodgkin Syndrome General Medicine Middle Aged Cytotoxic chemotherapy medicine.disease eye diseases Surgery Lymphoma Doxorubicin Vincristine sense organs Complication business Retinitis Pigmentosa Retinopathy |
| Zdroj: | The American Journal of the Medical Sciences. 303:319-320 |
| ISSN: | 0002-9629 |
| Popis: | Ocular toxicity is an uncommon complication of cytotoxic chemotherapy. Retinitis pigmentosa complicating cancer chemotherapy has not been reported. A patient with probable Usher's syndrome (congenital sensorineural deafness) had apparent acceleration of retinitis pigmentosa with blindness following cytotoxic chemotherapy for non-Hodgkin's lymphoma. Retinitis pigmentosa, a feature of Usher's syndrome, usually develops as a slowly progressive process. The rapid acceleration of retinopathy following tumor therapy suggests a possible relationship to the cytotoxic chemotherapy. Lymphocytes and fibroblasts from patients with Usher's syndrome are hypersensitive to the x-ray type of DNA-damaging agents. The DNA-damaging effects of chemotherapy may have accelerated the progression of retinitis pigmentosa in this patient. |
| Databáze: | OpenAIRE |
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