Characterization of swine leucocyte antigen alleles in a crossbred pig to be used in xenotransplant studies

Autor:	Matthew Tector, Leela L. Paris, Ross L. Blankenship, A. J. Tector, Luz M. Reyes, Aaron C. Miner, Rachel J. Blosser, Rashod F. Smith
Rok vydání:	2014
Předmět:	Heterozygote Swine Xenotransplantation medicine.medical_treatment Immunology Adaptive Immunity Biology Biochemistry Immune system Antigen Genetics medicine Animals Immunology and Allergy Gene Genotyping Alleles Crosses Genetic Histocompatibility Antigens Class I fungi Haplotype Histocompatibility Antigens Class II General Medicine Class II gene Domestic pig Haplotypes
Zdroj:	Tissue Antigens. 84:484-488
ISSN:	0001-2815
Popis:	We have characterized swine leucocyte antigen (SLA) classes I and II molecules of a domestic pig as a model for use in our xenotransplant program. Molecular characterization of the SLA classes I and II genes is critical to understanding the adaptive immune responses between swine and humans in the event of xenotransplantation. Seven swine leucocyte antigen genes (SLA-1, SLA-2, SLA-3, DQB1, DRB1, DQA and DRA) were analyzed and 15 alleles were identified. A novel DRA*w04re01 is reported for this limited polymorphic class II gene. The heterozygous haplotypes, Hp-32.0/35.0 and Hp-0.13/0.23 were deduced for our IU-pig model, for SLA classes I and II regions, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401b11f76f28b48c66b49ad6e51d4cd2 https://doi.org/10.1111/tan.12430 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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