Multifaceted targeting in cancer: the recent cell death players meet the usual oncogene suspects
| Autor: | Alexander Pintzas, Konstantinos Drosopoulos |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Programmed cell death
Fas Ligand Protein medicine.medical_treatment Clinical Biochemistry Antineoplastic Agents Apoptosis Biology Bioinformatics Inhibitor of Apoptosis Proteins Targeted therapy TNF-Related Apoptosis-Inducing Ligand Mice Therapeutic approach Drug Delivery Systems Neoplasms Drug Discovery medicine Animals Humans Mice Knockout Oncogene Proteins Pharmacology Clinical Trials as Topic Oncogene Tumor Necrosis Factor-alpha Cancer Oncogenes Receptors Death Domain medicine.disease Protein Structure Tertiary Gene Expression Regulation Neoplastic Clinical trial Receptors TNF-Related Apoptosis-Inducing Ligand Molecular network Drug Design Molecular Medicine Cancer development Signal Transduction |
| Zdroj: | Expert Opinion On Therapeutic Targets 11:5(May2007):641-659 |
| ISSN: | 1744-7631 1472-8222 |
| Popis: | Recent complicated advances towards the blueprinting of the altered molecular networks that lie behind cancer development have paved the way for targeted therapy in cancer. This directed a significant part of the research community to the development of specialized targeted agents, many of which are already available or in clinical trials. The prospect of patient-tailored therapeutic strategies, although very close to becoming a reality also raises the level of complexity of the therapeutic approach. This review summarizes the functions, in vivo expression patterns and aberrations of factors presently targeted or representing potential targets by therapeutic agents, focusing on those implicated in death receptor-induced apoptosis. The authors overview the regulation of these factors and death receptor-induced apoptosis by classical oncogenes (e.g., RAS, MYC, HER2) and their effectors/regulators, most of which are also being targeted. In addition, the importance of orthologic systemic approaches in future patient-tailored therapies are discussed. |
| Databáze: | OpenAIRE |
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