Case report: Post-traumatic memories triggered by donepezil in a dose-dependent pattern
| Autor: | Michael L. Wolff |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Memory Episodic Dose dependence Traumatic memories Stress Disorders Post-Traumatic chemistry.chemical_compound Piperidines Alzheimer Disease mental disorders medicine Humans Pharmacology (medical) Donepezil Aged 80 and over Dose-Response Relationship Drug business.industry Acetylcholinesterase chemistry Adverse drug event Anesthesia Indans Cholinesterase Inhibitors Geriatrics and Gerontology business medicine.drug |
| Zdroj: | The American journal of geriatric pharmacotherapy. 10(3) |
| ISSN: | 1876-7761 |
| Popis: | Background This case report describes a new adverse drug event due to use of donepezil in a patient with probable Alzheimer's Disease. Case summary While receiving a 10-mg dose of donepezil nightly, an 87-year old veteran of World War II experienced irrepressible memories of a kamikaze strike. This symptom did not occur at a 5-mg dose of donepezil and resolved with downward titration of this agent. Conclusions This sequence of dosage and symptoms suggests acetylcholinesterase inhibition was the trigger for release of these memories, which are otherwise mostly chronically repressed in this individual. |
| Databáze: | OpenAIRE |
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