Regulation of TLR7/9 signaling in plasmacytoid dendritic cells
| Autor: | Musheng Bao, Yong-Jun Liu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Review
Biology Biochemistry Immune tolerance Immune system Interferon Drug Discovery medicine Animals Humans Antigen-presenting cell Innate immune system TLR9 hemic and immune systems Dendritic Cells Cell Biology TLR7 Acquired immune system Cell biology Protein Transport Toll-Like Receptor 7 Toll-Like Receptor 9 Proteolysis Immunology Signal Transduction Biotechnology medicine.drug |
| Zdroj: | Protein & Cell. 4:40-52 |
| ISSN: | 1674-8018 1674-800X |
| Popis: | Plasmacytoid dendritic cells (pDCs), also known as type I interferon (IFN)-producing cells, are specialized immune cells characterized by their extraordinary capabilities of mounting rapid and massive type I IFN response to nucleic acids derived from virus, bacteria or dead cells. PDCs selectively express endosomal Toll-like receptor (TLR) 7 and TLR9, which sense viral RNA and DNA respectively. Following type I IFN and cytokine responses, pDCs differentiate into antigen presenting cells and acquire the ability to regulate T cell-mediated adaptive immunity. The functions of pDCs have been implicated not only in antiviral innate immunity but also in immune tolerance, inflammation and tumor microenvironments. In this review, we will focus on TLR7/9 signaling and their regulation by pDC-specific receptors. |
| Databáze: | OpenAIRE |
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