Cytomorphological pattern analysis of tubercular lymphandenopathies
| Autor: | Mamta Gupta, Abhishek Gupta, Afeefah Jamsheed, Anjali Khare, Rani Bansal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Tuberculosis Adolescent Morphological pattern Biopsy Fine-Needle Cytological Techniques India Pattern analysis Caseous necrosis Tuberculosis Lymph Node Haematoxylin Azure Stains Giemsa stain Necrosis 03 medical and health sciences chemistry.chemical_compound Humans Medicine Coloring Agents Hematoxylin Histiocyte 0303 health sciences Granuloma 030306 microbiology business.industry Mycobacterium tuberculosis medicine.disease Infectious Diseases chemistry Acid-fast Female Lymph Nodes business Papanicolaou Test |
| Zdroj: | Indian Journal of Tuberculosis. 67:495-501 |
| ISSN: | 0019-5707 |
| DOI: | 10.1016/j.ijtb.2020.07.001 |
| Popis: | Background The spectrum of morphological pattern in tubercular lymphandenopathies was observed to study the various cytomorphological patterns and their correlation with acid fast bacilli. Methods FNAC smears of 210 cases of granulomatous lymphadenitis stained with Giemsa, Pap and haematoxylin and eosin were used to analyze cytomorphological pattern and Zeihl Neelsen stained smears for acid fast bacilli (AFB) detection. Results 193 cases with necrotising granulomatous inflammation or positive acid fast bacilli were included. Age group 21–30 years was most common (38.3%) followed by age group 11–20 years (30.05%). Females constituted 66.3% of patients and 33.7% were male. Overall the most common pattern in present study was pattern A (Epitheloid granuloma with caseous necrosis 33.7% followed by pattern B (caseous necrosis with few scattered epitheloid histiocytes and lymphocytes) 31.1% and pattern C (caseous necrosis with suppurative inflammation) 30.6%, followed by pattern D (Caseous necrosis only) (3.6%) and pattern E (non necrotising epitheloid granuloma with positive acid fast bacilli) (1.03%). Acid fast bacilli were demonstrable in 175 cases (90.7%). Amongst the acid fast bacilli positive cases highest bacillary load 3+ grade was seen in pattern C in 6/59 (10.16%) cases. Conclusion FNAC is a simple useful tool and should be attempted in all cases of lymphandenopathies. It helps in establishing a diagnosis of tubercular etiology based on its morphological patterns however demonstration of acid fast bacilli on aspirated material confirms the diagnosis. |
| Databáze: | OpenAIRE |
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