Cardioprotection of Rosuvastatin Pre-conditioning on Myocardial Ischemia / Reperfusion Injury in a Rat Model
| Autor: | Pei-Xi Zhang, Zhi-Chao Xiao, Dai-Liang Hou, Cheng-Yun Zhou, Hong-Xia Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Ischemia medicine.disease_cause law.invention law Internal medicine medicine Cardiopulmonary bypass oxidative stress Rosuvastatin Myocardial ischemia/reperfusion Cardioprotection Multidisciplinary TUNEL assay business.industry apoptosis nutritional and metabolic diseases medicine.disease pre-conditioning Cardiology business Reperfusion injury rosuvastatin TP248.13-248.65 Oxidative stress Biotechnology medicine.drug |
| Zdroj: | Brazilian Archives of Biology and Technology, Volume: 62, Article number: e19190055, Published: 25 NOV 2019 Brazilian Archives of Biology and Technology v.62 2019 Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
| Popis: | This study aimed to investigate the cardioprotection of rosuvastatin pre-conditioning (R-Pre) in a rat model of myocardial ischemia / reperfusion (I/R). Male SD rats were assigned into three groups: sham group, I/R group and R-Pre group. Rats in I/R group and R-Pre group received ischemia for 30 min and reperfusion for 2 h. In R-Pre group, rats received intragastrical administration with rosuvastatin at 5 mg/kg once daily for 1 week. After 2-h reperfusion, the cardiac function was detected by ultrasonography; the blood was collected for biochemical analysis; the heart was collected for the TUNEL staining and immunohistochemistry for Bcl-2 and Bax. Our results showed rosuvastatin pre-conditioning for 1 week could significantly reduce the infarct ratio and improve the cardiac function after myocardial I/R injury, in which attenuation of oxidative stress and cell apoptosis played an important role. Our study provides evidence on the cardioprotection of rosuvastatin pre-conditioning and highlight the use of rosuvastatin before cardiopulmonary bypass. |
| Databáze: | OpenAIRE |
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