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Kidney stone formation (aka urolithiasis) is animportant prevalent condition in urological practicewith a high recurrence rate. Etiologically, urolithiasiscomprises a complex process resulting from asuccession of physicochemical events starting withsupersaturation, nucleation, growth, aggregation andfinally retention anywhere within the kidneys.Epidemiologically, calcium oxalate is recognized asthe predominant mineral in the majority of kidneystones where the mechanism of crystallization processis the main idea in urolithiasis. In the present study,effects of different subfractions derived from Coffeaarabica green beans methanol extract were assessedbased on the crystallization of calcium oxalate. Theireffects on size, number and type of calcium oxalatecrystals were indicated.Results revealed that ethyl acetate fraction possessesthe highest concentration of calcium ion that means thestrongest effect on dissolving calcium oxalatemonohydrate crystals compared with cystone. Inaddition, results confirmed that Coffea arabica extracthas antiurolithic activity via reducing crystal sizethrough stimulating the formation of calcium oxalatedehydrate (COD) crystals out from calcium oxalatemonohydrate (COM). The reduction of crystal sizealong with the diuretic effect enables the extract to playan important role in reducing the incidence ofurolithiasis and facilitating their elimination. |
