Chitosan and its derivatives as nanocarriers for siRNA delivery

Autor:	Carmen Remuñán-López, Ana Grenha, Sonia Al-Qadi
Rok vydání:	2012
Předmět:	Chitosan siRNA delivery Biodistribution Materials science Chitosan derivatives technology industry and agriculture Gene silencing Pharmaceutical Science Nanotechnology macromolecular substances Formulation parameters chemistry.chemical_compound chemistry Nanocarriers
Zdroj:	Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP
ISSN:	1773-2247
DOI:	10.1016/s1773-2247(12)50003-1
Popis:	The ability to specifically silence genes using siRNA has enormous potential for treating genetic diseases. However, siRNA instability and biodistribution issues still need to be overcome, and adequate delivery vehicles have proven indispensable in conveying siRNA to its target. Chitosan is a promising biopolymer for siRNA delivery, its interest stemming from its safety, biodegradability, mucoadhesivity, permeation enhancing effect and cationic charge, as well as amenability to undergo chemical modifications. Chitosan and its derivatives can be readily arranged into complexes or nanoparticles able to entrap and carry siRNA. Specific strategies have been adopted to improve chitosan-based vectors with regard to transfectability. However, further efforts are required to verify their value and adapt them to enhance therapeutic output prior to clinical application. This review emphasizes the potential of chitosan and its derivatives to develop nanocarriers for siRNA delivery. The properties of chitosan that are significant for transfectability and the most relevant findings are assessed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f89d3ae32fc8de8ef6242957f275ac2 https://doi.org/10.1016/s1773-2247(12)50003-1 Zobrazit plný text záznamu Full Text from ScienceDirect