Residual cervical lymphadenopathy after definitive treatment of nasopharyngeal carcinoma: fine needle aspiration cytology, computed tomography and histopathological findings
| Autor: | K.-H. Lim, Toh St, H-K. c Goh, Y. H. Goh, H W Yuen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Neoplasm Residual Time Factors medicine.medical_treatment Biopsy Fine-Needle Diagnosis Differential Necrosis Cervical lymphadenopathy Predictive Value of Tests Recurrence Cytology Biopsy medicine Humans Lymphatic Diseases Aged Retrospective Studies Singapore medicine.diagnostic_test business.industry Incidence Carcinoma Neck dissection Retrospective cohort study Nasopharyngeal Neoplasms General Medicine Middle Aged medicine.disease Surgery medicine.anatomical_structure Otorhinolaryngology Nasopharyngeal carcinoma Cervical lymph nodes Predictive value of tests Lymphatic Metastasis Neck Dissection Female Radiology Lymph Nodes medicine.symptom business Tomography X-Ray Computed Neck |
| Zdroj: | The Journal of laryngology and otology. 125(1) |
| ISSN: | 1748-5460 0022-2151 |
| Popis: | Background:Patients with nasopharyngeal carcinoma may have residual cervical lymphadenopathy after definitive treatment of the primary tumour and regional cervical nodal disease. Whether such lymphadenopathy truly represents persistent disease is unclear. There are few published studies addressing this clinical problem.Methods:We retrospectively and systematically reviewed the clinical records of 12 patients with nasopharyngeal carcinoma who had presented to a tertiary academic hospital, over an 11-year period, with suspected persistent cervical nodal disease after definitive radiotherapy or concurrent chemoradiotherapy. Findings on fine needle aspiration cytology and computed tomography scanning were correlated with final histopathological results.Results:The incidence of negative neck dissection was 41.7 per cent. The positive and negative predictive values of fine needle aspiration cytology in identifying disease were 100 and 42.9 per cent, respectively. Computed tomography scanning had a positive predictive value of 58.3 per cent in identifying disease.Conclusion:In patients treated definitively for nasopharyngeal carcinoma, residual cervical lymphadenopathy may not represent persistent disease. Head and neck surgeons involved in the management of these patients should bear in mind the current limitations of fine needle aspiration cytology and computed tomography in confirming the diagnosis pre-operatively. Salvage neck dissection may over-treat some of these patients. |
| Databáze: | OpenAIRE |
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