The possible role of uric acid in the ecology of Histoplasma capsulatum
| Autor: | Robert G. Garrison, G. F. Lockwood |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Urate Oxidase
Hypha Urease Veterinary (miscellaneous) Histoplasma Allantoinase Biology Applied Microbiology and Biotechnology Microbiology Ureohydrolases Amidohydrolases Cell wall chemistry.chemical_compound Allantoicase Allantoin chemistry.chemical_classification Pathogenic fungus Uric Acid Cryptococcus Enzyme chemistry Biochemistry biology.protein Uric acid Agronomy and Crop Science |
| Zdroj: | Mycopathologia et Mycologia Applicata. 35:377-388 |
| ISSN: | 1573-0832 0301-486X |
| DOI: | 10.1007/bf02050753 |
| Popis: | The results of this study indicate thatHistoplasma capsulatum in its saprophytic form is able to utilize the major nitrogenous constituent of avian manure as a nitrogen source. In addition, the enzymes responsible for the pathway of uric acid degradation to inorganic nitrogen have been demonstrated in cell-free systems. These enzymes include uricase, allantoinase, allantoicase, and urease. The uricase ofHistoplasma appears to be a cell wall or cell membrane-associated enzyme, while the other enzymes were located in the soluble portion of cell-free extracts. Cell-free extracts ofCryptococcus neoformans are actively uricolytic. It is suggested that this ability ofH. capsulatum hyphae to utilize uric acid and related compounds as growth substrates may in part explain the indisputable ecologic association of this pathogenic fungus with avian and possibly chiropteran-associated soils and habitats in those areas endemic for histoplasmosis. |
| Databáze: | OpenAIRE |
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