Diastolic dyssynchrony assessment by gated myocardial perfusion-SPECT in subjects who underwent cardiac resynchronization therapy

Autor: Diana Paez, Ganesan Karthikeyan, Jiménez-Heffernan A, Chetan Patel, Isabel Carvajal-Juarez, Luz M Pabon, Ernest V. Garcia, Teresa Massardo, Nilda Espinola-Zavaleta, Claudio Tinoco Mesquita, Amalia Peix, Sadaf Butt, Mani Kalaivani, Neftali Eduardo Antonio-Villa, Victor Marin, Olga Morozova, Alka Kumar, Erick Alexanderson-Rosas
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
medicine.medical_treatment
Cardiac resynchronization therapy
Diastole
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
Cardiac Resynchronization Therapy
03 medical and health sciences
Ventricular Dysfunction
Left
0302 clinical medicine
Internal medicine
Post-hoc analysis
medicine
Humans
Radiology
Nuclear Medicine and imaging
cardiovascular diseases
Prospective Studies
Aged
Ejection fraction
medicine.diagnostic_test
business.industry
Diastolic phase
Myocardial Perfusion Imaging
Stroke Volume
Middle Aged
medicine.disease
Heart failure
cardiovascular system
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography
Perfusion
Emission computed tomography
Follow-Up Studies
Zdroj: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 28(4)
ISSN: 1532-6551
Popis: Left ventricular diastolic dyssynchrony (LVDD) can be assessed by gated myocardial perfusion single-photon emission computed tomography (GMP-SPECT). LVDD is an area of interest in subjects who underwent cardiac resynchronization therapy (CRT). The aim of this post hoc analysis was to assess the role of LVDD in subjects with CRT who were followed up at 6-month period. Left ventricular diastolic dyssynchrony was assessed by GMP-SPECT at baseline and after CRT procedure in 160 subjects from 10 different cardiological centers. CRT procedure was performed as per current guidelines. Outcomes were defined as improvement in ≥1 New York Heart Association (NYHA) class, left ventricular ejection fraction (LVEF) by 5%, and reduction in end-systolic volume (ESV) by 15% and 5% points in Minnesota Living with Heart Failure Questionnaire. LVDD was defined as diastolic phase standard deviation ≥40 ± 14°. Improvement in NYHA functional class occurred in 105 (65.6%), LVEF in 74 (46.3%), decrease in ESV in 86 (53.8%), and Minnesota score in 85 (53.1%) cases. Baseline LV diastolic standard deviation was 53.53° ± 20.85 and at follow-up 40.44° ± 26.1283; (P
Databáze: OpenAIRE
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