The Dubin-Johnson syndrome: electron microscopic observation of hepatic pigment--a case study
| Autor: | Richard D. Ruppert, Nobuhisa Baba |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adolescent Biopsy Cytoplasmic Granules law.invention Pathogenesis Pigment Dubin–Johnson syndrome law Microscopy medicine Humans Electron microscopic biology medicine.diagnostic_test Staining and Labeling Chemistry Histocytochemistry Jaundice Chronic Idiopathic Acid phosphatase General Medicine Pigments Biological medicine.disease Microscopy Electron Liver visual_art biology.protein visual_art.visual_art_medium Electron microscope Lysosomes |
| Zdroj: | American journal of clinical pathology. 57(3) |
| ISSN: | 0002-9173 |
| Popis: | Pigment was recognized by light microscopy in a biopsy specimen of liver from a patient with the Dubin-Johnson syndrome. By electron microscopy, the pigment corresponded to dense bodies which consisted of aggregates of osmiophilic dense materials intermixed with fine granular and globular material, measuring 0.9 to 3 µ in diameter. Histochemically, a strong acid phosphatase activity was present in portions of these dense bodies. This finding suggests hepatic lysosomal dysfunction as the possible pathogenesis of this disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|