Elucidation of Factor VIII Activity Pharmacokinetics: A Pooled Population Analysis in Patients With Hemophilia A Treated With Moroctocog Alfa
| Autor: | Joan M. Korth-Bradley, Siv Jönsson, Lutz Harnisch, João A. Abrantes, Elisabet I. Nielsen |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Population 030204 cardiovascular system & hematology Pharmacology Hemophilia A 030226 pharmacology & pharmacy Young Adult 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Internal medicine medicine Moroctocog alfa Humans Drug Dosage Calculations Pharmacology (medical) Dosing Young adult Child education Aged Clinical Trials as Topic education.field_of_study Factor VIII business.industry Age Factors Infant Newborn Infant Factor VIII Activity Disposition Middle Aged NONMEM Child Preschool Female business |
| Zdroj: | Clinical Pharmacology & Therapeutics. 102:977-988 |
| ISSN: | 0009-9236 |
| DOI: | 10.1002/cpt.716 |
| Popis: | This study investigated the disposition of coagulation factor VIII activity in 754 patients with moderate to severe hemophilia A following the administration of moroctocog alfa, a B-domain deleted recombinant factor VIII. Data analyzed included patients aged 1 day to 73 years enrolled in 13 studies conducted over a period of 20 years in 25 countries. A two-compartment population pharmacokinetic model with a baseline model described the pooled data well. Body size, age, inhibitors, race, and analytical assay were identified as significant predictors of factor VIII disposition. In addition, simulations of prophylactic dosing schedules in several pediatric cohorts showed large variability and suggest that younger patients would require higher weight-adjusted doses than adolescents to achieve target factor VIII trough activity when receiving every other day or twice weekly dosing. |
| Databáze: | OpenAIRE |
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