MEK inhibitor as single agent in low grade serous ovarian and peritoneal cancer: a systematic review and meta-analysis
| Autor: | Lucia Musacchio, Anna Amela Valsecchi, Vanda Salutari, Giorgio Valabrega, Floriana Camarda, Valentina Tuninetti, Gaia Giannone, Michele Bartoletti, Claudia Marchetti, Sandro Pignata, Anna Fagotti, Giovanni Scambia, Massimo Di Maio, Domenica Lorusso |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Mitogen-Activated Protein Kinase Kinases
Low grade ovarian cancer Selumetinib Ovary General Medicine Binimetinib Chemo-resistance Settore MED/40 - GINECOLOGIA E OSTETRICIA Oncology Trametinib Humans Radiology Nuclear Medicine and imaging Female Protein Kinase Inhibitors MEK inhibitors Peritoneal Neoplasms |
| Popis: | Low grade serous carcinoma of the ovary and peritoneum (LGSC) is characterized by low response rates to chemotherapy and by MAPK pathway alterations. Phase II/III clinical trials tested different MEK inhibitors (MEKis) in this complex malignancy, with heterogenous results. Purpose of this systematic review and meta-analysis is to define activity and efficacy of these agents and explore differences in clinical outcomes related to RAS/RAF mutational status.In March 2022, we searched Pubmed, Web of Science, Scopus, and the major conference proceedings (ASCO, ESMO) for randomized and non-randomized clinical trials evaluating MEKi as single agent in recurrent LGSC. The screening was performed independently by two reviewers. Objective response rate (ORR) and progression-free survival (PFS) data were extracted, and RevMan 5.3 software was used for statistical analysis.A total of 4 clinical trials involving 648 patients were included. In the intention-to-treat population, use of a MEK inhibitor was not associated with a significant improvement in PFS, with a pooled Hazard Ratio equal to 0.75 (95 % CI: 0.30 - 1.86, P = 0.54). Heterogeneity was significant (IAlthough no statistically significant improvement in PFS was demonstrated, the available data show clear signals of activity, at least for some MEKis. |
| Databáze: | OpenAIRE |
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