FoxR2 promotes glioma proliferation by suppression of the p27 pathway
| Autor: | Xuejiao Liu, Mingshan Niu, Yiming Tu, Chenglong Yue, Guokun Zhuang, Shangfeng Gao, Rutong Yu, Dacheng Wang, Ning Liu, Di Zhou, Zhenglei Qi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Human glioma Cyclin E business.industry proliferation Bone Marrow Stem Cell p27 medicine.disease migration Nuclear accumulation 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cyclin D1 Oncology Downregulation and upregulation G1 arrest 030220 oncology & carcinogenesis Glioma glioma medicine Cancer research FoxR2 business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Xuejiao Liu 1, 2, * , Ning Liu 1, 4, * , Chenglong Yue 1, * , Dacheng Wang 1 , Zhenglei Qi 1 , Yiming Tu 1 , Guokun Zhuang 1 , Di Zhou 1 , Shangfeng Gao 1, 2 , Mingshan Niu 3 and Rutong Yu 1, 2 1 Insititute of Nervous System Diseases, Xuzhou Medical University, Xuzhou, Jiangsu, China 2 Brain Hospital, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China 3 Jiangsu Key Laboratory of Bone Marrow Stem Cell, Xuzhou Medical University, Xuzhou, Jiangsu, China 4 Department of Neurosurgery, Huzhou Central Hospital, Huzhou, Zhejiang, China * These authors contributed equally to this work Correspondence to: Mingshan Niu, email: msniu24@126.com Rutong Yu, email: yu.rutong@163.com Keywords: glioma, FoxR2, proliferation, migration, p27 Received: August 31, 2016 Accepted: April 14, 2017 Published: April 27, 2017 ABSTRACT FoxR2 plays an important role in the development of many human tumors. However, the effects of FoxR2 on tumorigenicity of human glioma remain unclear. In this study, we investigated the roles of FoxR2 in cell proliferation and invasion of glioma. We found that overexpression of FoxR2 promoted the proliferation, migration and invasion of glioma cells. Knockout of FoxR2 induced G1 arrest by decreasing the expression levels of cyclin D1, cyclin E and p-Rb. Mechanistically, upregulation of FoxR2 increased the level and activity of MMP-2 and decreased the expression of p27. Furthermore, overexpression of FoxR2 decreased the nuclear accumulation of p27. Taken together, these results indicate that upregulation of FoxR2 may confer enhanced tumorigenicity in glioma cells. |
| Databáze: | OpenAIRE |
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