The Cyclin-like Protein Spy1 Regulates Growth and Division Characteristics of the CD133+ Population in Human Glioma
| Autor: | Lisa A. Porter, Elizabeth Fidalgo da Silva, Ana C. deCarvalho, Brenna A. Market-Velker, Dorota Lubanska, Tom Mikkelsen |
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| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Human glioma Population Cell Cell Cycle Proteins Biology Bioinformatics medicine.disease_cause Brain cancer Mice 03 medical and health sciences 0302 clinical medicine Neural Stem Cells Antigens CD Glioma Biomarkers Tumor medicine Animals Humans AC133 Antigen Cancer biology education Glycoproteins 030304 developmental biology Cyclin Mice Inbred BALB C 0303 health sciences education.field_of_study Brain Neoplasms Life Sciences Cell Biology Prognosis medicine.disease medicine.anatomical_structure Oncology Tissue Array Analysis 030220 oncology & carcinogenesis Neoplastic Stem Cells Cancer research Peptides Carcinogenesis Microdissection Cell Division |
| Zdroj: | Biological Sciences Publications |
| ISSN: | 1535-6108 |
| DOI: | 10.1016/j.ccr.2013.12.006 |
| Popis: | Summary The heterogeneity of brain cancers, as most solid tumors, complicates diagnosis and treatment. Identifying and targeting populations of cells driving tumorigenesis is a top priority for the cancer biology field. This is not a trivial task; considerable variance exists in the driving mutations, identifying markers, and evolutionary pressures influencing initiating cells in different individual tumors. Despite this, the ability to self-renew and differentiate must be conserved to reseed a heterogeneous tumor mass. Focusing on one example of a tumor-initiating cell population, we demonstrate that the atypical cyclin-like protein Spy1 plays a role in balancing the division properties of glioma cells with stemness properties. This mechanistic insight may provide new opportunities for therapeutic intervention of brain cancer. |
| Databáze: | OpenAIRE |
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