Beneficial effects of quercetin-iron complexes on serum and tissue lipids and redox status in obese rats
Autor: | Sabri Cherrak, Nassima Mokhtari, Sid Ahmed Merzouk, Farid Berroukeche, Asmahan Imessaoudene, Mourad Elhabiri, Hafida Merzouk, Bachir Bensenane |
---|---|
Rok vydání: | 2015 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Iron Clinical Biochemistry Adipose tissue medicine.disease_cause Biochemistry 03 medical and health sciences chemistry.chemical_compound Internal medicine Hyperlipidemia Medicine Animals heterocyclic compounds Obesity Rats Wistar Molecular Biology Nutrition and Dietetics business.industry Body Weight Iron deficiency Metabolism Organ Size Carbohydrate medicine.disease Lipids Rats 030104 developmental biology Endocrinology chemistry Quercetin business Oxidation-Reduction Oxidative stress |
Zdroj: | The Journal of nutritional biochemistry. 29 |
ISSN: | 1873-4847 |
Popis: | Obesity is characterized by iron deficiency, carbohydrate and fat alterations as well as oxidative stress. Iron status monitoring is recommended because of the conventional oral iron preparations that frequently exacerbate the already present oxidative stress. Iron complexation by natural antioxidants can be exploited. We herein investigated the metabolic effects of quercetin (25 mg/kg/day), iron (2.5 mg Fe/kg/day) or quercetin-iron complexes (molar ratio 5:1; 25 mg/2.5 mg/kg/day) in animal models of obesity. Our results emphasized that obese rats displayed metabolic alterations that were worsened by iron supplementation. In contrast, quercetin used alone or as iron complex clearly prevented adipose fat accumulation and alleviated the hyperglycemia, hyperlipidemia, liver steatosis and oxidative stress. In addition, it induced a modulation of lipase activities in obese rats. Interestingly, quercetin-iron complexes showed enhanced beneficial effects such as a corrected iron deficiency in obese rats when compared to quercetin alone. In conclusion, antianemic, hypoglycemic, hypolipidemic and antioxidative effects of the quercetin-iron complexes shed a light on their beneficial use against obesity-related metabolic alterations. |
Databáze: | OpenAIRE |
Externí odkaz: |