Hypoxia-inducible factor-2a is associated with ABCG2 expression, histology-grade and Ki67 expression in breast invasive ductal carcinoma
| Autor: | Zhi-Heng Liu, Peng Su, Qin Huan, Gengyin Zhou, Yan Wang, Peng Gao, Lei Xiang, Guang-Jun Du |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
CA15-3
Pathology medicine.medical_specialty Histology Abcg2 Angiogenesis ABCG2(BCRP) Breast Neoplasms Breast invasive ductal cancer Metastasis Tissue microarray Pathology and Forensic Medicine Breast cancer MDR lcsh:Pathology Carcinoma medicine Basic Helix-Loop-Helix Transcription Factors ATP Binding Cassette Transporter Subfamily G Member 2 Humans Histology-grade biology Research Carcinoma Ductal Breast General Medicine medicine.disease Immunohistochemistry Neoplasm Proteins Ki-67 Antigen Tissue Array Analysis biology.protein HIF-2a ATP-Binding Cassette Transporters Female Neoplasm Grading Ki67 lcsh:RB1-214 IHC |
| Zdroj: | Diagnostic Pathology Diagnostic Pathology, Vol 7, Iss 1, p 32 (2012) |
| ISSN: | 1746-1596 |
| DOI: | 10.1186/1746-1596-7-32 |
| Popis: | Background Breast cancer is the most common cancer and the leading cause of cancer mortality in women worldwide. Hypoxia is an important factor involved in the progression of solid tumors and has been associated with various indicators of tumor metabolism, angiogenesis and metastasis. But little is known about the contribution of Hypoxia-Inducible Factor-2a (HIF-2a) to the drug resistance and the clinicopathological characteristics in breast cancer. Methods Immunohistochemistry was employed on the tissue microarray paraffin sections of surgically removed samples from 196 invasive breast cancer patients with clinicopathological data. The correlations between the expression of HIF-2a and ABCG2 as well as other patients' clinicopathological data were investigated. Results The results showed that HIF-2a was expressed in different intensities and distributions in the tumor cells of the breast invasive ductal carcinoma. A positive staining for HIF-2a was defined as a brown staining observed mainly in the nucleus. A statistically significant correlation was demonstrated between HIF-2a expression and ABCG2 expression (p = 0.001), histology-grade (p = 0.029), and Ki67 (p = 0. 043) respectively. Conclusion HIF-2a was correlated with ABCG2 expression, histology-grade and Ki67 expression in breast invasive ductal carcinoma. HIF-2a could regulate ABCG2 in breast cancer cells, and could be a novel potential bio-marker to predict chemotherapy effectiveness. The hypoxia/HIF-2a/ABCG2 pathway could be a new mechanism of breast cancer multidrug-resistance. Virtual slides http://www.diagnosticpathology.diagnomx.eu/vs/2965948166714795 |
| Databáze: | OpenAIRE |
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