Effect of experimental renal impairment on disposition of marbofloxacin and its metabolites in the dog

Autor: Pierre-Louis Toutain, V. Dupouy, G Costes, Valérie Laroute, Hervé P. Lefebvre, L Delesalle, Marc Schneider
Přispěvatelé: Physiopathologie et Toxicologie Expérimentales (UPTE), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, ProdInra, Migration
Jazyk: angličtina
Rok vydání: 1998
Předmět:
medicine.medical_specialty
040301 veterinary sciences
medicine.medical_treatment
Urology
Renal function
Administration
Oral
Pharmacology
Quinolones
030226 pharmacology & pharmacy
Beagle
0403 veterinary science
03 medical and health sciences
0302 clinical medicine
Dogs
Marbofloxacin
Pharmacokinetics
Anti-Infective Agents
Oral administration
medicine
Animals
Urea
Dog Diseases
Renal Insufficiency
Kidney
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
General Veterinary
business.industry
[SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
04 agricultural and veterinary sciences
Disposition
Nephrectomy
medicine.anatomical_structure
Area Under Curve
Creatinine
Injections
Intravenous
Female
business
medicine.drug
Fluoroquinolones
Glomerular Filtration Rate
Zdroj: Journal of Veterinary Pharmacology and Therapeutics
Journal of Veterinary Pharmacology and Therapeutics, Wiley-Blackwell, 1998, 21, pp.453-461
ISSN: 0140-7783
1365-2885
Popis: The pharmacokinetics of marbofloxacin was studied in eight healthy female Beagle dogs before and after moderate renal impairment was induced experimentally. A single intravenous (i.v.) administration and repeated administration for 8 days (2 mg/kg, once-a-day) of marbofloxacin were studied. Renal impairment was induced by a right kidney nephrectomy and electrocoagulation of the left kidney. An increase (P0.001) in the plasma concentrations of urea (from 3.8+/-0.7 to 9.8+/-2.1 mmol/L) and creatinine (from 78.8+/-3.4 to 145.8+/-22.3 micromol/L), and a significant decrease (2.9+/-0.3 vs 1.5+/-0.2 mL/kg/min) (P0.001) in glomerular filtration rate were observed in the renal-impaired dogs. The clearance of marbofloxacin was slightly decreased after the induction of renal failure (1.6+/-0.2 to 1.4+/-0.1 mL/kg/min) (P0.05), but no significant variation of volume of distribution at steady state (Vss) and mean residence time (MRT) was observed after intravenous administration of marbofloxacin (P0.05). Following oral administration of marbofloxacin, an increase in total area under the concentration time curve (AUC) was observed after renal failure (from 10372+/-1710 to 11459+/-1119 mg x min/L) (P0.05), but indices of accumulation were not modified. An increase (P0.01) in the AUC of N-oxide-marbofloxacin was observed after surgery. In conclusion, renal impairment has no biologically relevant influence on marbofloxacin disposition and there is no need for dosage adjustment of marbofloxacin in dogs with mild renal impairment.
Databáze: OpenAIRE
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