Mechanical and structural properties of bone in non-critical and critical healing in rat
| Autor: | Britta Seidt, Wolfgang Wagermaier, Peter Fratzl, Rebecca M. Hoerth, Georg N. Duda, Bettina M. Willie, Miheer Shah, Carolin Schwarz |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Materials science Non critical Bridging (networking) Nanostructure Medullary cavity medicine.medical_treatment Biomedical Engineering Mechanical properties Bone healing Critical size defect Osteotomy Biochemistry Bone and Bones Biomaterials Rats Sprague-Dawley Calcification Physiologic X-Ray Diffraction Hardness Elastic Modulus Bone material Scattering Small Angle medicine Animals Molecular Biology Wound Healing General Medicine X-ray scattering Microstructure Surgery Biomechanical Phenomena Primary bone Nanoparticles Crystallization Synchrotrons Biomedical engineering Biotechnology |
| Zdroj: | Acta Biomaterialia |
| ISSN: | 1878-7568 |
| Popis: | A fracture in bone results in a dramatic change of mechanical loading conditions at the site of injury. Usually, bone injuries heal normally but with increasing fracture gaps, healing is retarded, eventually leading to non-unions. The clinical situation of these two processes with different outcomes is well described. However, the exact relation between the mechanical environment and characteristics of the tissues at all levels of structural hierarchy remains unclear. Here we studied the differences in material formation of non-critical (1mm) and critical (5mm gap) healing. We employed a rat osteotomy model to explore bone material structure depending upon the different mechanical conditions. In both cases, primary bone formation was followed by secondary bone deposition with mineral particle sizes changing from on average short and thick to long and thin particles. Bony bridging occurred at first in the endosteal callus and the nanostructure and microstructure developed towards cortical ordered material organization. In contrast, in critical healing, instead of bridging, a marrow cavity closure was formed endosteal, exhibiting tissue structure oriented along the curvature and a periosteal callus with less mature material structure. The two healing processes separated between 4 and 6weeks post-osteotomy. The outcome of healing was determined by the varied geometrical conditions in critical and non-critical healing, inducing completely different mechanical situations. |
| Databáze: | OpenAIRE |
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