A prospective evaluation of patient-reported quality-of-life after (chemo)radiation for oropharyngeal cancer: Which patients are at risk of significant quality-of-life deterioration?
Autor: | Gerda M. Verduijn, Robert J. Baatenburg de Jong, Lisa Tans, Abrahim Al-Mamgani, Peter van Rooij, Aniel Sewnaik |
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Přispěvatelé: | Radiotherapy, Hematology, Otorhinolaryngology and Head and Neck Surgery |
Rok vydání: | 2013 |
Předmět: |
Adult
Male Risk medicine.medical_specialty medicine.medical_treatment Brachytherapy stomatognathic system Swallowing Quality of life SDG 3 - Good Health and Well-being Cyberknife otorhinolaryngologic diseases medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Aged business.industry Head and neck cancer Neck dissection Chemoradiotherapy Hematology Middle Aged Dry mouth medicine.disease humanities Surgery Radiation therapy Oropharyngeal Neoplasms stomatognathic diseases Oncology Quality of Life Female medicine.symptom business |
Zdroj: | Radiotherapy and Oncology, 106(3), 359-363. Elsevier Ireland Ltd |
ISSN: | 1879-0887 0167-8140 |
Popis: | Background and purpose To prospectively investigate the impact of different patients' characteristics on quality-of-life (QoL) after (chemo)radiation for oropharyngeal cancer (OPC). Materials and methods Between 2008 and 2011, 207 patients were treated with 46-Gy of (chemo)-IMRT followed by a boost by means of IMRT, brachytherapy (BT), or Cyberknife (CK). QoL-assessment was performed using the EORTC QLQ-C30, and QLQ-H&N35-questionnaires at baseline, end of treatment, 2, 4, 6weeks and 3, 6, 12, and 18months after treatment. The correlation between patients' characteristics (AJCC-stage, tumor subsite, chemotherapy, neck dissection, unilateral neck irradiation, and boost technique), and changes in QoL over time were investigated. Results At 18months, improvements were seen in QLQ-C30 emotional functioning, insomnia, and pain and QLQ-H&N35 pain and speech. The scores on QLQ-H&N35 swallowing returned to baseline level while the scores on dry mouth, sticky saliva, opening mouth, and teeth were significantly deteriorated compared to baseline. Boost techniques and unilateral neck irradiation were significantly predictive for dry mouth, swallowing and opening mouth while chemotherapy was correlated with changes on swallowing and opening mouth scales. Conclusions The most significant deterioration was seen in patient-related xerostomia. Boost technique, unilateral neck irradiation and chemotherapy were significantly predictive for QoL-changes over time. |
Databáze: | OpenAIRE |
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