Bioaccessibility of nickel and cobalt in synthetic gastric and lung fluids and its potential use in alloy classification
| Autor: | Ruth Danzeisen, Frédéric Gaidou, Adriana R. Oller, Katherine E. Heim, Violaine Verougstraete, Tony Brouwers |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Erythrocytes Alloy chemistry.chemical_element Biological Availability 010501 environmental sciences engineering.material Toxicology 030226 pharmacology & pharmacy 01 natural sciences Risk Assessment Metal Lethal Dose 50 Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Nickel Administration Inhalation Alloys Animals Humans Lung 0105 earth and related environmental sciences Gastric Juice technology industry and agriculture Extracellular Fluid General Medicine Cobalt Acute toxicity Bioavailability chemistry visual_art Toxicity visual_art.visual_art_medium engineering Composition (visual arts) Female Lysosomes Nuclear chemistry |
| Zdroj: | Regulatory toxicology and pharmacology : RTP. 110 |
| ISSN: | 1096-0295 |
| Popis: | This study investigated nickel and cobalt ion release from the metals and several alloys in synthetic gastric, as well as interstitial and lysosomal lung fluids. Results were used to calculate the relative bioaccessible concentrations (RBCs) of the metals. Nickel release from SS 316L powder in gastric fluid was >300-fold lower than from a simple mixture of powders of the same bulk composition. Gastric bioaccessibility data showed 50-fold higher metal releases per gram of sample from powder than massive forms. RBCs of nickel and cobalt in the alloy powders were lower, equal, or higher in all fluids tested than their bulk concentrations. This illustrates the fact that matrix effects can increase or decrease the metal ion release, depending on the metal ingredients, alloy type, and fluid, consistent with research by others. Acute inhalation toxicity studies with cobalt-containing alloy powders showed that the RBC of cobalt in interstitial lung fluid predicted acute toxicity better than bulk concentration. This example indicates that the RBC of a metal in an alloy may estimate the concentration of bioavailable metals better than the bulk concentration, and the approach may provide a means to refine the classification of alloys for several human health endpoints. |
| Databáze: | OpenAIRE |
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