High Grade T1 Papillary Urothelial Bladder Cancer Shows Prominent Peritumoral Retraction Clefting

Autor: Božo Krušlin, Tihana Džombeta
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
Cancer Research
Pathology
medicine.medical_specialty
Interleukin 8
Matrix metalloproteinase 2
Papillary urothelial carcinoma
Peritumoral retraction clefting
Urinary bladder
urologic and male genital diseases
Pathology and Forensic Medicine
Extracellular matrix
03 medical and health sciences
0302 clinical medicine
Biomarkers
Tumor
Humans
Medicine
Neoplasm
Neoplasm Invasiveness
Stage (cooking)
Survival rate
Aged
Aged
80 and over
Neoplasm Grading
Bladder cancer
business.industry
Interleukin-8
digestive
oral
and skin physiology
General Medicine
Middle Aged
medicine.disease
Carcinoma
Papillary
Survival Rate
030104 developmental biology
medicine.anatomical_structure
Urinary Bladder Neoplasms
Oncology
Urinary bladderPapillary urothelial carcinomaPeritumoral retraction cleftingMatrix metalloproteinase 2Interleukin 8
030220 oncology & carcinogenesis
Matrix Metalloproteinase 2
Immunohistochemistry
Female
Neoplasm Recurrence
Local
business
Follow-Up Studies
Zdroj: Pathology & Oncology Research. 24:567-574
ISSN: 1532-2807
1219-4956
DOI: 10.1007/s12253-017-0279-2
Popis: Differentiation of noninvasive from invasive papillary urothelial carcinoma can be challenging due to inability of proper orientation and thermal damage of transurethrally obtained material. The aim of this study was to analyze the presence and extent of peritumoral retractions in pT1 compared to pTa papillary urothelial carcinoma. Since peritumoral retractions may result from altered expression profiles of extracellular matrix proteins, we additionally analyzed the expression of matrix metalloproteinase 2 (MMP-2) and interleukin 8 (IL-8) in these tumors. The study comprised 50 noninvasive (pTa) and 50 invasive (pT1) cases of transurethrally obtained primary papillary urothelial carcinomas. The invasive nature of nests showing peritumoral retractions was confirmed immunohistochemically using antibody against collagen IV. Staining for MMP-2 and IL-8 was evaluated semiquantitatively using immunohistochemical staining index, calculated by multiplying the percentage of positive cells and staining intensity. Peritumoral retractions were found in 32% of pT1 carcinomas but in none of the pTa carcinomas. All tumors showing peritumoral retraction were high grade tumors. There was no statistically significant correlation between the expression of MMP-2 or IL-8 and the presence of peritumoral retractions or stage of the tumor (pTa vs. pT1). A statistically significant but weak correlation was found between MMP-2 and IL-8 expression (chi 2-test, p=0, 015). There was no statistically significant correlation between the presence of peritumoral retractions or MMP-2 expression and tumor recurrence and progression. Our study shows that, in doubtful cases, when differentiating between pTa and pT1 stages of papillary urothelial carcinoma, the presence of peritumoral retractions could favor the diagnosis of invasive neoplasm.
Databáze: OpenAIRE
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