Ala54Thr fatty acid-binding protein 2 (FABP2) polymorphism in recurrent depression: associations with fatty acid concentrations and waist circumference

Autor: Aart H. Schene, Claudi L H Bockting, Anja Lok, Maarten W. J. Koeter, Roel J. T. Mocking, Johanna Assies, Ieke Visser, Henricus G. Ruhé
Přispěvatelé: Amsterdam Neuroscience, Graduate School, Adult Psychiatry, Amsterdam Public Health, Cancer Center Amsterdam, Other departments, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Psychology and Experimental Psychopathology
Jazyk: angličtina
Rok vydání: 2013
Předmět:
DISORDER
Male
Threonine
Erythrocytes
Social Sciences
BIMODAL DISTRIBUTION
chemistry.chemical_compound
Eicosadienoic Acid
Recurrence
Risk Factors
Abdominal obesity
Randomized Controlled Trials as Topic
chemistry.chemical_classification
INSULIN-RESISTANCE
Multidisciplinary
Alanine
Arachidonic Acid
Fatty Acids
Middle Aged
ADIPOSE-TISSUE
ABDOMINAL OBESITY
Medicine
Arachidonic acid
Female
medicine.symptom
Waist Circumference
PITUITARY-ADRENAL-AXIS
Research Article
Adult
medicine.medical_specialty
Waist
Genotype
Science
Biology
Fatty Acid-Binding Proteins
Fatty acid-binding protein
Insulin resistance
RATIO
Eicosanoic Acids
Internal medicine
medicine
Humans
Depressive Disorder
Major
Polymorphism
Genetic
Fatty acid
medicine.disease
GENE
BODY-MASS INDEX
Endocrinology
chemistry
RISK-FACTORS
Body mass index
Zdroj: PLoS ONE, 8(12). Public Library of Science
PLOS ONE
PLoS ONE, Vol 8, Iss 12, p e82980 (2013)
PLoS ONE
PLoS ONE, 8(12):e82980. PUBLIC LIBRARY SCIENCE
ISSN: 1932-6203
Popis: BACKGROUND: Fatty acid (FA)-alterations may mediate the mutual association between Major Depressive Disorder (MDD) and cardiovascular disease (CVD). However, etiology of observed FA-alterations in MDD and CVD remains largely unclear. An interesting candidate may be a mutation in the fatty acid-binding protein 2 (FABP2)-gene, because it regulates dietary FA-uptake. Therefore, we aimed to test the hypotheses that in MDD-patients the FABP2 Ala54Thr-polymorphism would be (I) more prevalent than in sex- and age-matched controls, (II) associated with observed alterations in FA-metabolism, and (III) associated with CVD-risk factor waist circumference.METHODS: We measured concentrations of 29 different erythrocyte FAs, FABP2-genotype, and waist circumference in recurrent MDD-patients and matched never-depressed controls.RESULTS: FABP2-genotype distribution did not significantly differ between the 137 MDD-patients and 73 matched controls. However, patients with the Ala54Thr-polymorphism had (I) higher concentrations of especially eicosadienoic acid (C20:2ω6; P=.009) and other 20-carbon FAs, and associated (II) lower waist circumference (P=.019). In addition, FABP2-genotype effects on waist circumference in patients seemed (I) mediated by its effect on C20:2ω6, and (II) different from controls.CONCLUSIONS: Although Ala54Thr-polymorphism distribution was not associated with recurrent MDD, our results indicate that FABP2 may play a role in the explanation of observed FA-alterations in MDD. For Ala54Thr-polymorphism patients, potentially adaptive conversion of increased bioavailable dietary precursors into eicosadienoic acid instead of arachidonic acid might be related to a low waist circumference. Because this is the first investigation of these associations, replication is warranted, preferably by nutrigenetic studies applying lipidomics and detailed dietary assessment.
Databáze: OpenAIRE
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