Fibrillin-1 in incisional hernias: an immunohistochemical study in scar and non-scar regions of human skin and muscle fasciae

Autor: Claus Langer, Dieter P. Reinhardt, Fabio Quondamatteo, Edgar Brunner, László Füzesi, Martin Fricke, Lynn Y. Sakai
Rok vydání: 2008
Předmět:
Male
collagen
incisional hernias
cutis laxa
Human skin
growth-factor-beta
Extracellular matrix
Abdominal wall
Postoperative Complications
0302 clinical medicine
gene mutation
Fascia
fibrillin-1
Aged
80 and over
0303 health sciences
integumentary system
Microfilament Proteins
connective-tissue microfibrils
Middle Aged
Immunohistochemistry
Hernia
Abdominal
3. Good health
surgical procedures
operative
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Anatomy
Fibrillin
Adult
Reoperation
Risk
musculoskeletal diseases
skin
medicine.medical_specialty
Histology
neonatal marfan-syndrome
Incisional hernia
extracellular matrix
Fibrillins
scar
Collagen Type I
Cicatrix
03 medical and health sciences
systemic-sclerosis
fibroblasts
medicine
Humans
Hernia
extracellular-matrix
Molecular Biology
Ecology
Evolution
Behavior and Systematics
Aged
030304 developmental biology
Laparotomy
Wound Healing
business.industry
Abdominal Wall
Original Articles
Cell Biology
medicine.disease
elastic fiber
Surgery
Collagen Type III
Case-Control Studies
muscle fascia
business
Wound healing
Biomarkers
Developmental Biology
Zdroj: Journal of Anatomy. 212:674-685
ISSN: 1469-7580
0021-8782
Popis: Incisional hernias represent one of the most common complications after laparotomy. Specific pre-operative risk factors have not yet been identified. Recent studies indicate that changes in extracellular matrix components such as collagen I and collagen III may be involved in hernia development. In the present study we have evaluated the significance of fibrillin-1 in hernia development as one of the main components of the extracellular matrix. Tissue samples from non-scar skin and muscle fascia of 12 patients with incisional hernias as well as from the respective scar tissues were obtained. Corresponding tissue samples of 10 patients with normal postoperative wound healing served as controls. Distribution of fibrillin-1 was evaluated immunohistochemically. Differences in fibrillin-1 distribution in the non-scar tissues of muscle fascia have been found in patients with incisional hernia, compared to those without hernia. In scar regions of both patient groups, slight differences in the pattern of fibrillin-1 were observed. A tendency to a differential deposition of fibrillin-1 in skin samples, although hardly quantifiable, was observed as well. Our results suggest that fibrillin-1 is a relevant factor contributing to tissue stability. Disturbances in its deposition, even before scar formation, may be an important factor to the development of incisional hernias.
Databáze: OpenAIRE
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