In human patients, vascular water retention during DDAVP-related hyponatremia occurs mainly in the plasma volume and not in the erythrocyte
| Autor: | Alain Soupart, A. Kornreich, B. Namias, Guy Decaux |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Erythrocyte Indices Male medicine.medical_specialty Erythrocytes Sodium chemistry.chemical_element Diuresis Blood volume Peptide hormone Renal Agents Pathology and Forensic Medicine Internal medicine medicine Humans Deamino Arginine Vasopressin Administration Intranasal Blood Volume Chemistry Metabolic disorder Hemodynamics Albumin Reproducibility of Results Water nutritional and metabolic diseases General Medicine medicine.disease Red blood cell medicine.anatomical_structure Endocrinology Hematocrit Hyponatremia |
| Zdroj: | Journal of Laboratory and Clinical Medicine. 128:612-617 |
| ISSN: | 0022-2143 |
| DOI: | 10.1016/s0022-2143(96)90134-1 |
| Popis: | DDAVP-related hyponatremia induces a blood volume expansion, but the analysis of fluid distribution in the vascular compartment has given controversial results in previous animal and human studies. In 5 healthy males, hyponatremia was induced by DDAVP and a free water intake during 3 days. Serum sodium concentration decreased from 138 +/- 0.8 mEq/L to 123 +/- 2.7 mEq/L on day 3. The plasma volume measured by dilution of marked albumin rose from 3033 +/- 230 ml to 3320 +/- 295 ml (p0.01). The mean corpuscular volume measured by microhematocrit increased slightly from 91.5 +/- 3.8 pl to 92.6 +/- 3.7 pl (p0.02). The red blood cell volume calculated with hematocrit and plasma volume did not change significantly (2565 ml to 2567 ml; not significant). In the present work, we demonstrated that in males the expansion of the plasma compartment almost completely amounted for the water retention in the intravascular volume. The erythrocyte volume increased only slightly, a finding that is consistent with an almost perfect adaptation of the erythrocyte cells to the hypoosmolality. |
| Databáze: | OpenAIRE |
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