High cytoplasmic HuR expression is associated with advanced pT stage, high grade and increased microvessel density in urothelial bladder carcinoma
| Autor: | Łukasz Koperski, Łukasz Fus, Barbara Górnicka, Paweł Pihowicz, Janina M Marczewska |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Cytoplasm Urologic Neoplasms Pathology medicine.medical_specialty Angiogenesis Urinary Bladder medicine.disease_cause ELAV-Like Protein 1 Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Antigen medicine Carcinoma Humans Stage (cooking) Aged Aged 80 and over Carcinoma Transitional Cell Bladder cancer Urinary bladder Neovascularization Pathologic business.industry General Medicine Middle Aged medicine.disease Immunohistochemistry 030104 developmental biology medicine.anatomical_structure Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Microvessels Female business Carcinogenesis |
| Zdroj: | Annals of Diagnostic Pathology. 33:40-44 |
| ISSN: | 1092-9134 |
| Popis: | HuR (human antigen R) protein is a RNA binding protein that stabilizes the mRNA and controls the translation of genes involved in cell proliferation, differentiation, and carcinogenesis. Overexpression of HuR was reported in a variety of cancers, however its clinical significance in urothelial bladder cancer (UBC) is still unknown. Our aim is to investigate the association between HuR expression and selected histopathological factors, such as tumor grade, pT stage, regional lymph nodes status and microvessel density (MVD).We studied expression of HuR protein in 119 patients with UBC in stages pTis and pTa-pT4 using immunohistochemistry (IHC). Tumor MVD was evaluated immunohistochemically using anti-CD31 antibody.We observed no association between nuclear HuR immunoreactivity and tumor grade, stage or MVD. We found a significant association between cytoplasmic HuR positivity and high tumor grade, pT stage and MVD (p0,001). We also observed significantly higher MVD values in cases with positive cytoplasmic HuR expression (p0,001). No association between HuR immunoreactivity and lymph nodes status was found.Our results may suggest that HuR is involved in the process of acquiring malignant histopathological features and ability to invade the muscularis propria by UBC cells. Considering frequent difficulties in diagnosing UBC in specimens obtained from transurethral tumor resection and the risk of understaging, cytoplasmic HuR expression would suggest an advanced disease and necessitate serial sectioning of the specimen in search of muscle invasion. Association between HuR expression and MVD could suggest HuR involvement in the process of angiogenesis in UBC. |
| Databáze: | OpenAIRE |
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